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. 2022 May 18;13(5):470. doi: 10.1038/s41419-022-04919-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Normal (n = 8) and OA (n = 8) synovial biopsy samples were stained with aggrecan and DAPI. In normal (NL) synovium, aggrecan staining was predominantly observed within the intimal layer, but was also observed infrequently within the sub-intima (A–D two individuals shown as representative examples). In OA synovium, aggrecan staining was observed equally between the intima and sub-intima (E, F). The subcellular localization of aggrecan was also different between normal vs. OA samples. In normal samples aggrecan staining was diffuse throughout the cells with areas of increased staining adjacent to the nucleus (G arrows), while in OA samples a punctate pattern of staining was observed with increased staining adjacent to the nucleus (H arrows). Diagrammatic representations of aggrecan staining in normal (I) and OA (J) are also provided.