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. 2022 May 18;13(5):470. doi: 10.1038/s41419-022-04919-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Human (normal and OA) and rat (normal and OA) synovium was doubled labeled for aggrecan (red) and CD90 (green), a marker of synovial progenitor/MSCs in both human and rat. In normal human synovium (A), CD90 (B) and aggrecan (C) were found to be highly co-localized, mainly at the intimal surface, but also within the sub-intimal layer adjacent to vessels. In OA synovium (D), CD90 (E) and aggrecan (F) were also found to be highly co-localized in the intimal and sub-intimal layers. In normal rat synovium (G), CD90 (H) positive cells were also found to express aggrecan (I). In OA synovium (J), CD90 (K) positive cells also expressed aggrecan (L). Scale bars equal 50 µm.