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. 2022 May 18;13(5):470. doi: 10.1038/s41419-022-04919-1

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — Mice with or without joint injury (ACL-X) were subjected to intraarticular injection (A). Mouse joints without ACL-X injury, but with injection of aggrecan show little difference vs. non-injected joints in terms OARSI score (D). ACL-X injured joints post-aggrecan injection demonstrate an increased level of Safranin O staining in the cartilage surfaces (B) vs. PBS controls (C) and demonstrate a significant reduction in OARSI score (D). Scale bars equal 50 µm.