Table 1.

GO-terms significantly associated with breast cancer among significant GO-terms found using Hy-test, moderated t-test and both procedures.

Sign. GO-term	GO ID	Analysis	Term size	BR term size	p value
Cell cycle checkpoint signaling	GO:0000075	Hy-test	167	34	< 1.11E−16
Mitotic spindle checkpoint signaling	GO:0071174	Hy-test	38	14	< 1.11E−16
Regulation of cell cycle	GO:0051726	Hy-test	951	134	< 1.11E−16
Regulation of cell cycle process	GO:0010564	Hy-test	594	102	< 1.11E−16
Spindle assembly checkpoint signaling	GO:0071173	Hy-test	37	15	< 1.11E−16
Cell surface receptor signaling pathway	GO:0007166	Mod t-test	2485	643	< 1.11E−16
Cell–cell signaling	GO:0007267	Mod t-test	1545	436	< 1.11E−16
Regulation of signal transduction	GO:0009966	Mod t-test	2734	619	< 1.11E−16
Regulation of signaling	GO:0023051	Mod t-test	3107	719	< 1.11E−16
Signal transduction	GO:0007165	Mod t-test	5175	1210	< 1.11E−16
Angiogenesis	GO:0001525	Both	493	171	< 1.11E−16
Cell communication	GO:0007154	Both	5681	1342	< 1.11E−16
Cell population proliferation	GO:0008283	Both	1835	473	< 1.11E−16
Mitotic cell cycle	GO:0000278	Both	833	217	< 1.11E−16
Tissue development	GO:0009888	Both	1749	483	< 1.11E−16

Term size is the number of genes that compose a GO-term; BR term size is the number of GO-term genes associated with breast cancer; p-value is computed by using the hypergeometric distribution.