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. 2022 May 18;12:8278. doi: 10.1038/s41598-022-12070-2

Table 1.

Demographic and clinical characteristics of patients with keratoconus at the initial diagnosis.

Total Pediatric (≤ 18 y/o) Adult (> 18 y/o) p-value
Number of patients 152 20 (13.2%) 132 (86.8%)
Number of eyes 288 37 (12.8%) 251 (87.2%)
Laterality 1.0000a
OD 146 19 (51.3%) 127 (50.6%)
OS 142 18 (48.7%) 124 (49.4%)
Sex 1.0000a
Male 95 (62.5%) 13 (65.0%) 82 (62.1%)
Female 57 (37.5%) 7 (35.0%) 50 (37.9%)
Age at KC diagnosis (years)
Median (IQR) 24.2 (11.2) 15.1 (3.4) 24.8 (10.7)  < .0001b*
Mean ± SD 25.8 ± 8.4 15.3 ± 1.8 27.4 ± 7.9
Clinical appearance
Vogt's striae 32 (11.1%) 3 (8.1%) 29 (11.6%) 0.7794a
Fleischer ring 25 (8.7%) 4 (10.8%) 21 (8.4%) 0.5424a
Cone morphology 0.7147a
Nipple 33 (11.5%) 4 (10.8%) 29 (11.5%)
Oval 161 (55.9%) 23 (62.2%) 138 (55.0%)
Globus 94 (32.6%) 10 (27.0%) 84 (33.5%)
Cone location 0.3582a
Central 189 (65.6%) 27 (73.0%) 162 (64.5%)
Paracentral 99 (34.4%) 10 (27.0%) 89 (35.5%)
Comorbidity
Atopic dermatitis 9 (5.9%) 1 (5.0%) 8 (6.1%) 1.0000a
Eye rubbing 19 (12.5%) 4 (20.0%) 15 (11.4%) 0.2810a

aFisher exact test. bWilcoxon rank-sum test. KC: keratoconus. OD: right eye. OS: left eye. y/o: years old. SD: standard deviation. *statistical significance according to the sequential Bonferroni-type procedure, because the smallest p was < i/46* 0.05 for the 41multiple tests in Tables 1 and 2.