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. 2022 May 18;13(5):468. doi: 10.1038/s41419-022-04924-4

Fig. 7. FSP1-CoQ10-NADH pathway is involved in SIO-induced retinal pathology resembling age-related macular degeneration in vivo.

Fig. 7

A 4-HNE/FSP1 immunofluorescence in retinal sections of mice receiving vehicle, SIO and/or Fer-1 injections. Scale bar = 200 µm. B Quantitative analysis of fluorescent intensity of FSP1. n = 6 (biological replicates). C Quantitative analysis of fluorescent intensity of 4-HNE. n = 6 biological replicates. D NADH level of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). E NAD+/NADH ratio of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). F CoQ10 level of SIO-induced retinal pathology resembling age-related macular degeneration with/without Fer-1 treatment. n = 6 (biological replicates). *p < 0.05, **p < 0.01, ***p < 0.001.