Fig. 3. Large-scale correlations in signaling suggest a generalized response that is compound independent.

A Unsupervised hierarchical clustering of A375 signalome cells treated by 122 active drugs according to their activity scores. Due to technical error, Geminin reporter was not measured for all drugs and was thus discarded. Results from all 12 reporters can be seen in Supplementary Fig. 4I for the subset of drugs that for which Geminin data are available. B Scatter plot showing the correlation between the activities of the p38 and p53 reporters after 48 h of treatment with 122 active drugs. C Heatmap showing the pairwise Pearson correlations between the different A375 Signalome clones, after 48 h of treatment with 122 active drugs. D A model proposing how drugs with different mechanisms may converge into two major signaling states. While each of the drugs has different targets, many of the targets affect the same sensing mechanism that later governs the p53- vs p38-signaling states. Source data are provided with this paper.