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. Author manuscript; available in PMC: 2022 Nov 5.
Published in final edited form as: Nat Genet. 2022 May 5;54(5):573–580. doi: 10.1038/s41588-022-01054-7

Extended Data Fig. 6. Prediction accuracy of different polygenic prediction methods across different proportions of shared causal variants between populations.

Extended Data Fig. 6

Phenotypes were simulated using 1% of randomly sampled causal variants. 100%, 70% or 40% of the causal variants were shared across populations. Shared causal variants had a cross-population genetic correlation of 0.7. SNP heritability was fixed at 50%. PRS were trained using 100K EUR samples and 20K non-EUR (EAS or AFR) samples. Numerical results are reported in Supplementary Table 7.