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. Author manuscript; available in PMC: 2022 Nov 5.
Published in final edited form as: Nat Genet. 2022 May 5;54(5):573–580. doi: 10.1038/s41588-022-01054-7

Extended Data Fig. 4. Prediction accuracy of different polygenic prediction methods across different ratios of EUR vs. non-EUR GWAS sample sizes.

Extended Data Fig. 4

Phenotypes were simulated using 1% of randomly sampled causal variants (shared across populations), a cross-population genetic correlation of 0.7, and SNP heritability of 50%. PRS were trained using 120K EUR samples without non-EUR samples, 100K EUR and 20K non-EUR (EAS or AFR) samples, 80K EUR and 40K non-EUR samples, or 60K EUR and 60K non-EUR samples. Numerical results are reported in Supplementary Table 5.