Table 2.

Associations of rest-activity parameters with white blood-cell-based inflammatory markers

Dependent variables	Rest-activity rhythm parameters	Model 1		Model 2		Model 3
		Beta (95% CI)	P	Beta (95% CI)	P	Beta (95% CI)	P
WBC*	RA	−0.26 (−0.31 −0.21)	<0.001	−0.16 (−0.22, −0.11)	<0.001	−0.10 (−0.15, −0.05)	<0.001
	IV	−0.01 (−0.06, 0.04)	0.920	0.05 (−0.0004, 0.10)	0.038	0.03 (−0.03, 0.08)	0.260
	IS	−0.07 (−0.12, −0.02)	0.012	−0.04 (−0.09, 0.01)	0.114	−0.01 (−0.06, 0.03)	0.570
	M10	−0.06 (−0.07, −0.04)	<0.001	−0.05 (−0.06, −0.04)	<0.001	−0.03 (−0.04, −0.02)	<0.001
	L5	0.19 (0.13, 0.25)	<0.001	0.1 (0.04, 0.15)	0.001	0.07 (0.02, 0.12)	0.008
Neutrophils †	RA	−0.19 (−0.23, −0.15)	<0.001	−0.12 (−0.16, −0.07)	<0.001	−0.07 (−0.11, −0.03)	0.003
	IV	0.01 (−0.03, 0.04)	0.366	0.04 (0.004, 0.08)	0.013	0.02 (−0.02, 0.06)	0.115
	IS	−0.05 (−0.08, −0.01)	0.007	−0.02 (−0.06, 0.01)	0.108	−0.003 (−0.04, 0.03)	0.642
	M10	−0.05 (−0.06, −0.03)	<0.001	−0.04 (−0.05, −0.03)	<0.001	−0.02 (−0.04, −0.01)	<0.001
	L5	0.13 (0.08, 0.18)	<0.001	0.07 (0.02, 0.11)	0.006	0.05 (−0.002, 0.09)	0.054
NLR‡	RA	−0.08 (−0.11, −0.05)	<0.001	−0.07 (−0.1, −0.04)	0.002	−0.05 (−0.08, −0.01)	0.064
	IV	0.04 (−0.002, 0.07)	0.057	0.04 (0.009, 0.08)	0.031	0.03 (−0.007, 0.06)	0.252
	IS	−0.02 (−0.05, 0.01)	0.250	−0.01 (−0.04, 0.02)	0.551	0.0004 (−0.03, 0.03)	0.716
	M10	−0.02 (−0.03, −0.01)	<0.001	−0.02 (−0.03, −0.01)	<0.001	−0.01 (−0.02, −0.004)	0.009
	L5	0.05 (0.02, 0.07)	0.014	0.03 (0.005, 0.06)	0.090	0.03 (−0.002, 0.06)	0.243
SII‡	RA	−25.0 (−33.4, −16.5)	<0.001	−20.2 (−29.0, −11.5)	0.001	−15.2 (−24.4, −6.0)	0.019
	IV	6.7 (−1.6, 14.9)	0.104	9.3 (1.1, 17.2)	0.035	6.0 (−2.4, 14.0)	0.199
	IS	−4.5 (−12.7, 3.8)	0.383	−2.8 (−12.3, 6.6)	0.650	0.22 (−9.4, 9.5)	0.756
	M10	−6.0 (−7.9, −4.0)	<0.001	−4.9 (−6.9, −3.0)	<0.001	−3.2 (−5.1, −1.4)	0.023
	L5	13.8 (6.4, 21.2)	0.005	9.2 (1.9, 16.4)	0.038	7.4 (0.05, 14.8)	0.124

^*P values were calculated using log-transformed WBC count as outcome; N=8089 for model 1, N=7486 for model 2, N=7413 for model 3

^†P values were calculated using log-transformed neutrophil count as outcome; N=8074 for model 1, N=7471 for model 2, N=7400 for model 3

^‡P values were calculated using log-transformed values as outcome; N=8074 for model 1, N=7471 for model 2, N=7394 for model 3

Model 1: Adjusted for age, sex, race

Model 2: Adjusted for age, sex, race, ratio of family income to poverty level, physical activity, and smoking

Model 3: Adjusted for age, sex, race, ratio of family income to poverty level, physical activity, smoking, BMI, CVD, cancer, stroke, diabetes and hypertension