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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Trends Neurosci. 2022 Apr 13;45(6):483–498. doi: 10.1016/j.tins.2022.03.004

Figure 1. Synaptic ectodomain shedding.

Figure 1.

A. Numerous transmembrane and GPI-anchored proteins undergo proteolytic processing, resulting in the release of a soluble extracellular fragment in a process called ES. B-D. ES at the synapse can be mediated by MMPs (B), ADAM10 (C) and BACE1, ADAM17, MT3-MMP and MT5-MMP (D). Cleaved proteins are indicated next to their main protease; however, each substrate can be cleaved by multiple proteases. Of note, for several proteins it is still unclear whether they are found only in one side of the synapse or both.