Table 1.
Examples of synaptic proteins known to undergo ectodomain shedding, including the cleaving proteases and regulating stimuli.
| Synaptic protein | Protease | Stimuli | References |
|---|---|---|---|
| APP | ADAM10 BACE1 γ-secretase* |
Neuronal activity Nicotinic receptor activation NMDAR activation |
[41,42] |
| CD44 | MMP9 | 5-HT7R activation | [56] |
| CDH2 | MT5-MMP ADAM10 |
Bicuculline-induced neuronal activity NMDA-induced neuronal activity |
[26, 50] |
| CHL1 | BACE1 γ-secretase* |
N.D. | [12, 57] |
| CNTNAP2 | MMP9 | cLTP | [20] |
| EFNA2 | ADAM10 | EFNA2/EPHA3 binding | [4] |
| ICAM5 | MMP9 | NMDAR and AMPAR activation | [19, 51] |
| L1CAM | MMPs ADAM10 BACE1 |
PMA-induced PKC signaling NMDA incubation |
[23, 53, 55] |
| NCAM | ADAM10 ADAM17 BACE1 |
EFNA5/EPHA3 binding | [15, 24, 49] |
| Nectin1 | ADAM10 | Constitutive NMDAR activation |
[52] |
| NGL3 | MMPs γ-secretase* |
LTD induced by NMDA Low frequency stimulation (LTD) |
[58] |
| NGR1 | MT3-MMP | N.D. | [27, 103] |
| NLGN1 | MMP9 ADAM10 |
NMDA+glutamate Interaction with sNRXN Pilocarpine-induced epileptic seizures |
[5, 6, 18] |
| NLGN2 | MMP9 | NMDA+glutamate | [18] |
| NLGN3 | ADAM10 MMP9 |
NMDA+glutamate | [18, 48] |
| NOTCH | ADAM10 | Binding to Delta ligands | [66] |
| NPTXR | ADAM17/TACE | mGluR1/5-dependent LTD | [21] |
| NRG1 | BACE1 ADAM10 ADAM17 |
NMDA Kainate |
[62, 63] |
| NRXNs | MMP γ-secretase |
KCl-induced neuronal activity | [45] |
| NRXN3(3 | ADAM10 ADAM17/TACE α-secretase γ-secretase* |
N.D. | [46, 47] |
| SEZ6 SEZ6L |
BACE1 | N.D. | [59] |
| SIRPα | MMPs | KCl Activity-induced tyrosine phosphorylation |
[70, 104] |
N.D. not determined.
*
Not sheddase, intramembrane cleavage.