. Author manuscript; available in PMC: 2023 Jun 1.

Published in final edited form as: Trends Neurosci. 2022 Apr 13;45(6):483–498. doi: 10.1016/j.tins.2022.03.004

Table 3.

Synaptic ectodomains detected in hCSF in CNS diseases.

Protein	Disorder	Levels	Reference

sCNTNAP2	ASD	Decreased	[20]

sICAM5	Acute encephalitis	Increased	[87]
	MS	Decreased	[89]
	Temporal lobe epilepsy	Increased	[88]

sLICAM	SZ	Decreased	[77]
	Dementia, AD	Increased	[78]
	Glioblastoma	Increased	[90]

sNCAM	SZ	Increased	[77]
sNCAM	MS	Decreased	[86]

NRXN2and 3	Preclinical AD	Decreased	[96]
	Prodromal AD	Increased
	AD	Increased

sp75NTR	AD	Decreased	[79]