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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Gastroenterology. 2022 Feb 24;162(7):2032–2046.e12. doi: 10.1053/j.gastro.2022.02.032

Figure 1. Muc5ac is associated with stromal modulation in PC.

Figure 1.

(A) Representative images and (B) quantitative analyses of immunohistochemistry (IHC) for stromal markers on tumor sections from KC and KCM mice at 50 weeks of age (n=4/ group). Expression of α-SMA, FN1, and HA was significantly reduced, accompanied by a nonsignificant increase in expression of FAP in KCM tumors, as compared to KC tumors. (C) Quantitative PCR analysis on RNA isolated from KC/ KCM tumors (n=4/ group) and (D) CAFs (isolated from 50 weeks KC and KCM tumors, n=4/ group) demonstrate heterogeneity in stromal markers. t-test *p<0.05.