Table 1.
Baseline Demographic and Clinical Data
| Controls (n=10) | NAFLD (n=37) | p-value | |
|---|---|---|---|
| Age (years) | 33 (11.7) | 51 (12.0) | <0.0001 |
| Sex - (female %) | 4 (40%) | 20 (54%) | 0.49 |
| Ethnicity [n (%)] | |||
| Caucasian | 5 (50%) | 17 (46%) | 0.009 |
| Hispanic | 0 (0%) | 14 (38%) | |
| African-American | 3 (30%) | 1 (3%) | |
| Other | 2 (20%) | 5 (13%) | |
| BMI (kg/m 2 ) | 21.8 (2.0) | 33.3 (5.5) | <0.0001 |
| ALT (U/L) | 16 (7.7) | 62 (54) | <0.0001 |
| HbA1C (%) | 5.3 (0.3) | 5.9 (0.9) | 0.03 |
| Fasting glucose (mg/dL) | 89 (5.2) | 108 (21.6) | <0.0001 |
| Fasting Insulin (mcU/mL) | 7.9 (5.3) | 23.9 (9.6) | <0.0001 |
| HOMA-IR | 1.8 (1.2) | 6.5 (3.2) | <0.0001 |
| Triglycerides (mg/dL) | 61 (18) | 171 (70) | <0.0001 |
| Waist circumference (cm) | 77.4 (5.6) | 108.4 (13.4) | <0.0001 |
| Percent Fat (%) | 24 (8.7) | 40 (7.4) | <0.0001 |
| Fat mass (kg) | 14.6 (4.8) | 37.0 (12.9) | <0.0001 |
| Lean mass (kg) | 44.9 (10.4) | 51.3 (10.1) | 0.09 |
| Fat Free Mass (kg) | 47.5 (10.9) | 53.9 (10.5) | 0.10 |
| Visceral Adipose Tissue volume (cm 3 ) | 256 (127) | 2257 (1114) | <0.0001 |
| Baseline Energy Expenditure (kcal/min) a | 1.57 (0.47) | 1.88 (0.33) | 0.03 |
| Baseline Respiratory Quotient A | 0.87 (0.02) | 0.89 (0.04) | 0.12 |
| Postprandial Change in Respiratory Quotient | 0.08 (0.26) | −0.01 (0.03) | 0.31 |
| Mixed Meal Dose (kCal) | 613 (101) | 683 (127) | 0.11 |
Demographic and clinical characteristics are presented as mean (SD) unless otherwise stated.
A
n=9 Controls and n=36 NAFLD