Skip to main content
. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Alcohol. 2022 Feb 26;101:17–26. doi: 10.1016/j.alcohol.2022.02.003

Figure 4. Ethanol CPP increases postsynaptic strength on PV-INs.

Figure 4.

(a) Averaged representative traces of spontaneous excitatory postsynaptic currents (sEPSCs) from PV-INs from female mice (top) and male (mice) from control (black), CPP (red), or CPA (blue) groups. Scale bars 5 pA, 2 ms. (b) Representative timecourses of sEPSCs. Scale bars 20 pA, 200 ms. (c) Ethanol CPP increased the amplitude of sEPSCs from PV-INs relative to controls (Two-way ANOVA: F2,62 = 9.7, p<0.001 main effect of group, *:p<0.05, ***:p<0.001 post-tests vs same-sex control). PV-INs from male mice had smaller sEPSC amplitude than those from female mice (Two-way ANOVA: F1,62 = 4.1, *:p<0.05 main effect of sex). (d) No effect of ethanol conditioning or mouse sex on the frequency of sEPSCs from PV-INs. (e) Differences in sEPSC decay time were not detected. n/N = 8-14 cells from 3-5 mice per group.