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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Trends Neurosci. 2022 Apr 21;45(6):471–482. doi: 10.1016/j.tins.2022.03.010

Figure 1. Pathways connecting the central clock activity and peripheral metabolic rhythms.

Figure 1.

The schematic illustrates the key neurohumoral pathways connecting the SCN central clock with the peripheral metabolic organs in the regulation of diurnal rhythmicity in baseline endogenous glucose production (EGP), glucose tolerance, and insulin sensitivity. Abbreviations: SNS, sympathetic nervous system; PSNS, parasympathetic nervous system; GH, growth hormone; IGF, insulin-like growth factor.