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. Author manuscript; available in PMC: 2023 Jun 1.
Published in final edited form as: Trends Neurosci. 2022 Apr 21;45(6):471–482. doi: 10.1016/j.tins.2022.03.010

Figure 2. Endogenous glucose production (EGP) and its sensitivity to insulin-mediated suppression in healthy individuals and in the extended dawn phenomenon.

Figure 2.

In normal physiology, baseline EGP and its sensitivity to insulin-mediated suppression both peak at wakening. Disruption of the clock-mediated insulin sensitivity rhythmicity at waking can lead to reduced insulin sensitivity at this time point and contribute to the extended dawn phenomenon in type 2 diabetes (T2D). The schematic illustrates one pattern of disruption out of many possible different ways of disruption.