Table 2.
UVA for mOS in mHSPC Based on Baseline Lab Values.
| Variable | N | Hazard Ratio (95% CI)‡ | P-value* | |
|---|---|---|---|---|
| Hgb Status (Normal: 12.9 – 16.1) | Abnormal | 97 | 2.33 (1.18–4.62) | 0.015 |
| Normal | 68 | - | - | |
| Hgb at Optimal Cut (11.8) | Above | 106 | 0.28 (0.15–0.51) | <0.001 |
| Below | 59 | - | - | |
| Platelets Status (Normal: 150 – 400) | Abnormal | 25 | 0.64 (0.25–1.63) | 0.348 |
| Normal | 140 | - | - | |
| Platelets at Optimal Cut (259) | Above | 56 | 2.11 (1.17–3.82) | 0.013 |
| Below | 109 | - | - | |
| Neutrophils Status (Normal: 0.67 – 6.41) | Abnormal | 18 | 1.33 (0.56–3.17) | 0.513 |
| Normal | 147 | - | - | |
| Neutrophils at Optimal Cut (3.08) | Above | 102 | 1.04 (0.56–1.93) | 0.897 |
| Below | 63 | - | - | |
| Lymphocytes Status (Normal: 0.72 – 3.29) | Abnormal | 26 | 1.05 (0.49–2.25) | 0.910 |
| Normal | 139 | - | - | |
| Lymphocytes at Optimal Cut (2.7) | Above | 13 | 0.84 (0.29–2.44) | 0.745 |
| Below | 152 | - | - | |
| Monocytes Status (Normal: 0.14 – 0.71) | Abnormal | 24 | 0.65 (0.26–1.66) | 0.369 |
| Normal | 141 | - | - | |
| Monocytes at Optimal Cut (0.53) | Above | 57 | 1.25 (0.68–2.32) | 0.472 |
| Below | 108 | - | - | |
| Eosinophils Status (Normal: 0.05 – 0.29) | Abnormal | 67 | 1.30 (0.72–2.36) | 0.379 |
| Normal | 98 | - | - | |
| Eosinophils at Optimal Cut (0.11) | Above | 75 | 0.54 (0.29–1.02) | 0.057 |
| Below | 89 | - | - | |
| Basophils Status (Normal: 0 – 0.07) | Abnormal | 29 | 3.20 (1.69–6.07) | <0.001 |
| Normal | 136 | - | - | |
| Basophils at Optimal Cut (0.1) | Above | 24 | 3.69 (1.91–7.12) | <0.001 |
| Below | 141 | - | - | |
| NLR at Optimal Cut (1.67) | Above | 121 | 0.94 (0.49–1.82) | 0.864 |
| Below | 44 | - | - | |
| NER at Optimal Cut (23) | Above | 76 | 1.08 (0.55–2.10) | 0.822 |
| Below | 63 | - | - | |
| PLR at Optimal Cut (135.5) | Above | 104 | 1.82 (0.93–3.55) | 0.079 |
| Below | 61 | - | - | |
| MLR at Optimal Cut (0.396) | Above | 52 | 2.40 (1.31–4.39) | 0.005 |
| Below | 113 | - | - | |
| BLR at Optimal Cut (0.0142) | Above | 97 | 1.35 (0.73–2.50) | 0.338 |
| Below | 68 | - | - |
*
The p-value is calculated by Cox proportional hazard model; CI - 95% confidence interval.
Hgb = hemoglobin, NLR = neutrophil-to-lymphocyte ratio, NER = neutrophil-to-eosinophil ratio, PLR = platelet-to-lymphocyte ratio, MLR = monocyte-to-lymphocyte ratio, BLR = basophil-to-lymphocyte ratio