Table 3.
UVA for Progression Free Survival (PFS) in mHSPC Based on Baseline Lab Values.
| Variable | N | Hazard Ratio (95% CI)‡ | P-value* | |
|---|---|---|---|---|
| Hgb Status (Normal: 12.9 – 16.1) | Abnormal | 97 | 1.77 (1.15–2.71) | 0.010 |
| Normal | 68 | - | - | |
| Hgb at Optimal Cut (11.8) | Above | 106 | 0.34 (0.23–0.51) | <0.001 |
| Below | 59 | - | - | |
| Platelets Status (Normal: 150 – 400) | Abnormal | 25 | 0.78 (0.43–1.40) | 0.408 |
| Normal | 140 | - | - | |
| Platelets at Optimal Cut (259) | Above | 56 | 2.05 (1.36–3.08) | <0.001 |
| Below | 109 | - | - | |
| Neutrophils Status (Normal: 0.67 – 6.41) | Abnormal | 18 | 1.29 (0.70–2.36) | 0.417 |
| Normal | 147 | - | - | |
| Neutrophils at Optimal Cut (3.08) | Above | 102 | 0.81 (0.54–1.22) | 0.312 |
| Below | 63 | - | - | |
| Lymphocytes Status (Normal: 0.72 – 3.29) | Abnormal | 26 | 1.04 (0.62–1.76) | 0.878 |
| Normal | 139 | - | - | |
| Lymphocytes at Optimal Cut (2.7) | Above | 13 | 2.07 (1.10–3.90) | 0.023 |
| Below | 152 | - | - | |
| Monocytes Status (Normal: 0.14 – 0.71) | Abnormal | 24 | 0.87 (0.50–1.51) | 0.617 |
| Normal | 141 | - | - | |
| Monocytes at Optimal Cut (0.53) | Above | 57 | 0.89 (0.57–1.37) | 0.587 |
| Below | 108 | - | - | |
| Eosinophils Status (Normal: 0.05 – 0.29) | Abnormal | 67 | 1.39 (0.93–2.08) | 0.109 |
| Normal | 98 | - | - | |
| Eosinophils at Optimal Cut (0.11) | Above | 75 | 0.58 (0.38–0.88) | 0.011 |
| Below | 89 | - | - | |
| Basophils Status (Normal: 0 – 0.07) | Abnormal | 29 | 1.97 (1.20–3.25) | 0.007 |
| Normal | 136 | - | - | |
| Basophils at Optimal Cut (0.1) | Above | 24 | 2.39 (1.42–4.01) | 0.001 |
| Below | 141 | - | - | |
| NLR at Optimal Cut (1.67) | Above | 121 | 0.72 (0.47–1.12) | 0.149 |
| Below | 44 | - | - | |
| NER at Optimal Cut (23) | Above | 76 | 1.35 (0.85–2.13) | 0.199 |
| Below | 63 | - | - | |
| PLR at Optimal Cut (135.5) | Above | 104 | 1.55 (1.00–2.40) | 0.049 |
| Below | 61 | - | - | |
| MLR at Optimal Cut (0.396) | Above | 52 | 1.52 (1.00–2.33) | 0.052 |
| Below | 113 | - | - | |
| BLR at Optimal Cut (0.0142) | Above | 97 | 0.76 (0.51–1.14) | 0.187 |
| Below | 68 | - | - | |
*
The p-value is calculated by Cox proportional hazard model; CI - 95% confidence interval.
Hgb = hemoglobin, NLR = neutrophil-to-lymphocyte ratio, NER = neutrophil-to-eosinophil ratio, PLR = platelet-tolymphocyte ratio, MLR = monocyte-to-lymphocyte ratio, BLR = basophil-to-lymphocyte ratio