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. 2022 Apr 7;14(1):55–74. doi: 10.1016/j.jcmgh.2022.03.013

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Ultrastructural changes in hCEL-HYB1 mice. (A) Representative transmission electron micrographs of pancreas from C57BL/6J, hCEL-HYB1, and hCEL mice aged 5 months. hCEL-HYB1 mice show slightly dilated endoplasmic reticula and vacuolation (black arrow). Scale bar = 4 μm. (B) Degradative vacuoles in an acinar cell from an hCEL-HYB1 mouse aged 6 months. Scale bar = 0.5 μm. Pancreatic tissue sections from 12-month-old hCEL-HYB1 mice showing protein aggregates in cytoplasm (Scale bar = 1 μm) (C); large autophagy vesicles with undegraded high-density contents (Scale bar = 2 μm) (D); as well as evident dilated endoplasmic reticula in some acinar cells (Scale bar = 4 μm) (E).