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. Author manuscript; available in PMC: 2023 May 19.
Published in final edited form as: J Neurosurg. 2021 Nov 19;137(1):184–191. doi: 10.3171/2021.7.JNS21190

TABLE 2.

Demographic and baseline clinical characteristics of patients undergoing DBS, according to LRRK2 status

Clinical Characteristic IPD DBS (n = 14) LRRK2 DBS (n = 9) p Value
Male 13/14 (92.86) 7/9 (77.78) 0.53
Age at PD motor symptom onset, yrs 52.33 ± 9.01 50.11 ± 13.56 0.72
Age at PD diagnosis, yrs 53.00 ± 9.12 51.11 ± 12.83 0.72
Site of onset
 Arm 7/14 (50.00) 3/9 (33.3) 0.39
 Leg 4/14 (28.57) 3/9 (33.3) >0.99
 Gait 1/14 (7.14) 3/9 (33.3) 0.27
Duration of disease at diagnosis, yrs 0.67 ± 0.72 1.67 ± 1.22 0.03
Disease duration at levodopa institution, yrs 2.69 ± 1.93 6.25 ± 6.80 0.14
Age at surgery, yrs 64.1 ± 6.33 63.11 ± 15.09 0.97
Duration of disease (diagnosis) at surgery, yrs 10.59 ± 6.68 11.11 ± 5.13 0.52
Duration of disease (symptoms) at surgery, yrs 10.53 ± 6.27 12.78 ± 4.38 0.22
Median LEDD at surgery (IQR) 938 (498.5) 1228 (491) 0.09
Median UPDRS-III score at surgery (IQR) 9 (11) 16 (21) 0.13

Data given as mean ± SD or number (%), unless otherwise indicated.