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. 2022 May 5;12:862564. doi: 10.3389/fonc.2022.862564

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Copyright © 2022 Duan, Wang, Zhang, Yuan, Tang, Zhou and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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miRNA-195-5p was down-regulated in LUAD and cell lines. (A, B)The expression of miRNA-195-5p in lung cancer examine by TCGA datasets. (C) The tumor stage of miRNA-195-5p in TCGA-LUAD examine by the UALCAN. (D) The lymph node metastases of miRNA-195-5p in TCGA-LUAD examined by the UALCAN. (E, F) The expression of miRNA-195-5p in lung cancer determines by GEO datasets. (G) The expression of miRNA-195-5p in LUAD cell lines was determined by qRT-PCR assay. (H–J)The overall survival and disease-specific survival of miRNA-195-5p in LUAD determine by the TCGA-LUAD dataset and clinical samples. (K, L) Univariate and multivariate Cox regression analyses were performed to determine miRNA-195-5p as an independent prognostic factor in the TCGA LUAD dataset. **P < 0.01; ***P < 0.001.