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. 2022 May 5;9:834593. doi: 10.3389/fmolb.2022.834593

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Copyright © 2022 Xie, Tian, Tang, Zou, Zheng, Wu, Zeng, Wu, Xie and Xie.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Construction of a necroptosis-related lncRNAs signature. (A) LASSO coefficient profiles of the nine model lncRNAs in the training cohort. (B) A coefficient profile plot of the LASSO model was produced against the log (lambda) sequence and to screen the optimal parameter at which the vertical lines were drawn. (C) Expression profiles of nine model lncRNAs between the tumor and normal samples shown as boxplots (****, **, and ns indicate p < 0.0001, <0.01, and no significance, respectively). (D) Relative expression levels of TAPT1-AS1, HCP5, C12orf77, and USP30-AS1 in MCF10A, MDA-MB-231, and MDA-MB-468 cell lines (n = 3; ****, ***, **, and * indicate p < 0.0001, < 0.001, < 0.01, and < 0.05, respectively). (E) Overall survival curves based on high and low expression levels of each model lncRNA.