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. 2022 May 18;13(5):466. doi: 10.1038/s41419-022-04918-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Diagram of the experimental procedure. B HDAC6 inhibitor protects against ischemia-induced neuronal death through MIF acetylation. Mice were infected with either AAV-MIF-2A-mCherry or AAV-K78R-2A-mCherry and administered tubastatin A every day for 3 days. Ischemia was then induced and the infarct volume was analyzed by TTC staining in brain sections. C Quantification analysis of the lesion volume is shown in (B). Data shown were independent points and mean; one-way ANOVA, n = 6; *p < 0.05; ***p < 0.001. D–F Neurological deficits were evaluated by the mNSS test (D), adhesive-removal test (E), and foot fault assays (F). Data shown were independent points and mean; two-way ANOVA; n = 6; *p < 0.05; **p < 0.01; ***p < 0.001. G Diagram of the experimental procedure. H Aspirin protects against ischemia-induced neuronal death through MIF acetylation. Mice were infected with AAVs and administered aspirin. Ischemia was induced and infarct volume was analyzed by TTC staining in brain sections. I Quantification analysis of the lesion volume is shown in (H). Data shown were independent points and mean; one-way ANOVA, n = 6; **p < 0.01. J–L Neurological deficits were evaluated by the mNSS test (J), adhesive-removal test (K), and foot fault assays (L). Data shown were independent points and mean; two-way ANOVA; n = 6; ***p < 0.001.