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. 2022 May 18;13:2726. doi: 10.1038/s41467-022-30412-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Domain structure and evolutionary conservation of Equinox and VWDE. Presence of an Equinox-like protein (blue squares) and VWDE (pink squares). b equinox is expressed dorsal to laminB⁺ DVB epidermal cells in uninjured animals. n = 3 independent experiments. c H&E staining of sagittal sections shows epidermal wound covering of transverse wounds (left, n = 1 experiment). Mature epidermis (prss12⁺, rootletin⁺) is observed by 18 hpa at the wound (middle). Wound-induced equinox expression following amputation is observed at the outer layer (right). n = 3 independent experiments.