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. 2022 May 18;13:2726. doi: 10.1038/s41467-022-30412-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Schematic of the 10X scRNA-seq experiment, UMAP and dot plots show equinox expression in the epidermis and in neoblast/neoblast progeny. b UMAP and dot plots show equinox expression throughout the epidermal lineage. c equinox wound-induced expression is mostly neoblast independent at 6 but not at 18 hpa. d Dorsal view of wound sites show equinox expression mostly in mature epidermis at 6 hpa and in epidermal progenitors at 18 hpa. Blue arrows, epidermal progenitors. White arrows, mature epidermis. e Histograms show downregulation of dorsal epidermis markers and dorsal epidermal progenitor markers after bmp4 RNAi. UMAP and dot plots show equinox expression is enriched in dorsal epidermal progenitors at 16 hpa. Colored box, area depicted in pictures. Data shown in (c, d) are representative of four independent experiments. Scale bars, 100 μm (c) and 10 μm (d).