Fig. 7. equinox is required for regeneration contexts that need blastema outgrowth.

a equinox is required for regeneration through blastema formation. n = 3 independent experiments for sagittal amputations, n = 2 independent experiments for all other injuries. Blue lines, injury. Scale bars, 100 μm. b Model: (1) wound healing involves formation of a wound epidermis lacking basement membrane separation from underlying tissues. (2) Wound signaling is promoted and sustained by equinox expression in the wound epidermis. (3) Positional information regeneration is promoted by wound signaling and leads to specification of missing cell types in proliferating neoblasts at wounds. These steps promote initiation of blastema formation in regeneration.