Fig. 2.

(A) The distinctions between the AT₂R in the two states. Purple and orange cartoons show inactive-like and active-like AT₂R, respectively. In the zoom-in views, the sum of distance between the Cα atoms of S^2.40 to K^5.63 and S^2.40 to K^6.25 was shown to measure the movement of TM5-TM6. The dihedral among the Cα atoms of L^8.54, V^7.56, C^7.54, and C^7.47 was applied for the movement of H8. (B) The free energy landscape composed of the sum of distance and dihedral. Arrows show the position of inactive-like and active-like AT₂R on the landscape. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)