Table 1.
Comparative analysis of ancillary testing and pharmacologic response in cough-phenotypic traits originating from the lower airways. CA, classic asthma; COPD, chronic obstructive pulmonary disease; CVA, cough variant asthma; FeNO, fractional exhaled nitric oxide; ICS, inhaled corticosteroids; LTRA, leukotriene receptor antagonist; NAEB, non-asthmatic eosinophilic bronchitis
| Spirometry41 |
Bronchial hyperresponsiveness (methacholine)41,55,151 |
FeNO (ppb)59,103,105 |
Therapeutic response41,42,44, 45, 46, 47, 48, 49 |
||||
|---|---|---|---|---|---|---|---|
| Parental steroids | Bronchodilators | ICS | LTRAs | ||||
| CA | Abnormal | Present | 30–40 | (+)ve | (+)ve | (+)ve | (+)ve |
| NAEB118 | Normal | Absent | 22.5–31.7 | (+)ve | (−)ve | (+)ve | (+)ve |
| CVA | Normal | Present or Borderline | 30–40 | (+)ve | (+)ve | (+)ve | (+)ve |
| COPD | Abnormal | Present | NA | (+)ve | (+)ve | Not fully established | (−)ve |