Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 2;14(1):75–99. doi: 10.1016/j.jcmgh.2022.03.011

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Senolytic treatment eliminates senescent cells in mice fibrotic livers. The MBL^-/- and WT mice (n = 6 per group) were garaged with D+Q every 3 weeks for 3 times during the fibrosis establishment. (A) Representative immunofluorescence staining of α-SMA (green) and p16 (red), p-H2.X (red), or Ki67 (red) in liver tissues. (B) Representative immunofluorescence staining of α-SMA (red) and Bax (green) or Bcl2 (green) in liver tissues. (C) The p53 and p21 protein levels in liver tissues were assessed by Western blot analysis. (D) The mRNA levels of senescence-related genes in liver tissues were assessed by quantitative reverse-transcription PCR analysis. Scale bars: 100 μm. Data are presented as means ± SEM. ∗P < .05, ∗∗P < .01, 1-way analysis of variance followed by Tukey post hoc tests for multiple group comparisons. CCL, chemokine (C-C motif) ligand; CXCL, chemokine (C-X-C motif) ligand; DAPI, 4′,6-diamidino-2-phenylindole; HPF, high-power field; IL, interleukin; MMP, matrix metalloproteinase.