REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Brilliant Violet 711-anti-CD8a	Biolegend	Cat# 100748; RRID: AB_2562100
FITC-anti-CD4	Biolegend	Cat# 100406; RRID: AB_312691
APC-anti-CD45R	Biolegend	Cat# 103212; RRID: AB_312997
PE-Cy7-anti-CD19	Biolegend	Cat# 115520; RRID: AB_313655
PB-anti-CD38	Biolegend	Cat# 102720; RRID: AB_10613468
FITC-anti-CD69	Biolegend	Cat# 104506; RRID: AB_313109
APC-anti-CD62L	Biolegend	Cat# 104412; RRID: AB_313099
Percp-eflour 710-anti-PD-1	Invitrogen	Cat# 46-9981-82; RRID: AB_11151142
PE-Cy7-anti-TIM-3	Invitrogen	Cat# 25-5870-82; RRID: AB_2573483
APC-anti-Ly108	Biolegend	Cat# 134610; RRID: AB_2728155
PE-anti-CD45.1	Biolegend	Cat# 110708; RRID: AB_313497
PerCP-Cy5.5-anti-CD45.1	Biolegend	Cat# 110728; RRID: AB_893346
FITC-anti-CD45.2	Invitrogen	Cat# 11-0454-85; RRID: AB_465062
PB-anti-CD45.2	Biolegend	Cat# 109820; RRID: AB_492872
APC-Cy7-anti-CD44	Biolegend	Cat# 103028; RRID: AB_830785
AF700-anti-Thy1.1(CD90.1)	Biolegend	Cat# 202528; RRID: AB_1626241
FITC-anti-TNAα	Biolegend	Cat# 506304; RRID: AB_315425
APC-anti-IFNγ	Invitrogen	Cat# 17-7311-82; RRID: AB_469504
PE-IL-2	Biolegend	Cat# 503808; RRID: AB_315302
Alexa Fluor647-anti-TCF-1	Cell Signaling Technology	Cat# 6709S; RRID: AB_2797631
PE-TOX	Invitrogen	Cat# 12-6502-82; RRID: AB_10855034
PerCP-Cy5.5-anti-Ki67	Biolegend	Cat# 652424; RRID: AB_2629531
anti-γH2AX	Cell Signaling Technology	Cat# 2577S; RRID: AB_2118010
Chemicals, peptides, and recombinant proteins
PBS	HyClone	Cat# SH30013.04
DMEM Media (High Glucose)	Gibco	Cat# C11995500CP
RPMI Medium (1640)	Gibco	Cat# 11875-093
Fetal Bovine Serum （FBS）	Royacel	Cat# RY-F22-05
Penicillin-Streptomycin Solution	Hyclone	Cat# SV30010
Trypsin-EDTA	Gibco	Cat# 25200-072
Hepes Buffer Solution	Bioind	Cat# 03-025-1B
Sodium Pyruvate	Gibco	Cat# 11360-070
L-Glutamine	Gibco	Cat# 25030081
MEM Non-Essential Amino Acids Solution	Gibco	Cat# 11140-050
β-mercaptoethanol	Sigma	Cat# B6891
Live FDV506	Invitrogen	Cat# 65-0866-18
CFSE	Selleck	Cat# S8269
Cell Proliferation Dye 450	Invitrogen	Cat# 65-0842-85
Mito-Sox	Invitrogen	Cat# M36008
PMA	Sigama	Cat# P8139-5MG
Ionomycin	Fcmacs	Cat# FMS-FZ208
eBioscience Brefeldin A	Biolegend	Cat# 420601
Fixation Buffer	Biolegend	Cat# 420801
Permeabilization Buffer	Biolegend	Cat# 421002
Foxp3/Transcription Factor Staining Buffer	Invitrogen	Cat# 00-5223-56; Cat# 00-5123-43
Foxp3/Transcription Factor Permeabilization Buffer	Invitrogen	Cat# 00-8333-56
TransIT-293	Mirusbio	Cat# MIR2700
Polybrene	Santa Cruz	Cat# SC-134220
PerfectStart Green qPCR SuperMix	TransGen Bitoech	Cat# AQ601-04
NMN	Yeasen Biotechnology	Cat# 60303ES80
NAD+	MCE	Cat# HY-B0445
Ficoll-Paque	GE	Cat# 17-1440-03
Percoll	Cytiva	Cat# 17089109
OVA peptides	Abcepta Biotech	N/A
Human IL-2	Pepro Tech	Cat# 200-02-500
Human IL-7	Novoprotein	Cat# CX47
RetroNectin Recombinant Human Fibronectin Fragment	TaKaRa	Cat# T100A
Critical commercial assays
Negative CD8 Sorting kit	Biolegend	Cat# 480044
PI/Annexin V staining kit	Life technologies	Cat# V13245
Anti-PE	Biolegend	Cat# 480080
PrimeScript RT Master Mix	TaKaRa	Cat# RR036B
RNeasy Mini Kit	Qiagen	Cat# 74104
NAD+/NADH Assay kit	Beyotime	Cat# S0175
ATP Assay kit	Beyotime	Cat# S0026
ADP/ATP -Lite Assay kit	Vigorous Biotechnology	Cat# T008
Experimental models: Cell lines
293FT	ATCC	CRL-3249
B16-F10	ATCC	CRL-6475
B16-OVA	Bo Huang Lab	N/A
Experimental models: Organisms/strains
Mouse: C57BL/6	Vital River	N/A
Oligonucleotides
Cas9 for Cd38 see Table S1	This paper	N/A
Recombinant DNA
pMSGV	Addgene	Cat# 64269
pMSGV-Thy1.1	This paper	N/A
pMSGV-Thy1.1-CD38	This paper	N/A
pLVX-mCherry-YFP	Yuzheng Zhao Lab	N/A
pLVX-mCherry-FiNad	Yuzheng Zhao Lab	N/A
pMSGV-mCherry-YFP	This paper	Recombinated form pLVX-mCherry-YFP
pMSGV-mCherry FiNad	This paper	Recombinated form pLVX-mCherry-FiNad
pEco	Clontech	Cat# HG-VNC0832
Software and algorithms
Prism8	Graphpad-prism	Prism - GraphPad
Flowjo	BD	FlowJo | FlowJo, LLC
GEPIA 2 online tool	Zemin Zhang Lab	http://gepia2.cancer-pku.cn/#correlation