REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit mAb PTGS2 Cox2 (D5H5) XP®	Cell Signalling	Cat#12282 (WB 1:1000; IF 1:150)
Rabbit mAb PARP	Cell Signalling	Cat#9532 (WB 1:1000)
Rabbit mAb Phospho-PKA C (Thr197) (D45D3)	Cell Signalling	Cat#5661 (WB 1:1000)
Rabbit mAb Phospho-CREB (Ser133) (87G3)	Cell Signalling	Cat#9198 (WB 1:1000)
Rabbit mAb GAPDH (14C10)	Cell Signalling	Cat#2118 (WB 1:10000)
Mouse mAb b-Actin	Sigma-Aldrich	Cat#A5441 (WB 1:20000)
Mouse mAb Glucagon	Sigma-Aldrich	Cat#G2654 (IF 1:200)
Rabbit anti-Glucagon	Cell Signalling	Cat#G2760 (IF 1:150)
Mouse mAb Insulin	Sigma-Aldrich	Cat#I2018 (IF 1:300)
Mouse mAb Cytochrome C	MBL	Cat#BV-3026-3 (IF 1:100)
Rabbit mAb Ki-67 (SP6)	ThermoFisher Scientific	Cat# MA5-14520 (IF: 1:150)
Anti-Mouse IgG (whole molecule)–Peroxidase antibody produced in rabbit	Sigma-Aldrich	Cat#A9044 (WB 1:5000)
Anti-Rabbit IgG (whole molecule)–Peroxidase antibody	Sigma-Aldrich	Cat#A0545 (WB 1:5000)
IRDye® 680RD Goat anti-Mouse IgG (H + L)	LICOR	Cat#926-68070 (WB 1:15000)
IRDye® 800CW Goat anti-Rabbit IgG (H + L)	LICOR	Cat#926-32211 (WB 1:15000)
Goat anti-Rabbit IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 488	ThermoFisher Scientific	Cat#A32731 (IF 1:800)
Goat anti-Mouse IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 568	ThermoFisher Scientific	Cat#A11004 (IF 1:800)
Donkey anti-Mouse IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor Plus 555	ThermoFisher Scientific	Cat#A32773 (IF 1:800)
Donkey anti-Rabbit IgG (H + L) Highly Cross-Adsorbed Secondary Antibody, Alexa Fluor 647	ThermoFisher Scientific	Cat#A31573 (IF 1:800)
Donkey anti-Goat IgG (H + L) Cross-Adsorbed Secondary Antibody, Alexa Fluor 488	ThermoFisher Scientific	Cat#A11055 (IF 1:800)
Chemicals, peptides, and recombinant proteins
ONO 8139 (PTGER1 antagonist)	Tocris	Cat#5406
TNFα	ProSpec-Tany TechnoGene	Cat#CYT-252
BL001	In house	N/A
L-161,982 (PTGER4 antagonist)	Caymen Chemical	Cat#10011565
IFNϒ	ProSpec-Tany TechnoGene	Cat#CYT-358
IL1β	ProSpec-Tany TechnoGene	Cat#CYT-273
Critical commercial assays
Prostaglandin E2 (PGE2) ELISA	R&D Systems	Cat#KGE004B
Cell Death Detection ELISA	Merck	Cat#11544675001
Deposited data
Microarray data	Gene Expression Omnibus repository	GSE94505; GSE94505; GSE104322
Experimental models: cell lines
1023A iPSCs	Prof. D. Eiziric, ULB Center for Diabetes Research, Medical Faculty, Universite Libre de Bruxelles (ULB), Belgium	N/A
RAW264.7	ATCC	https://www.atcc.org/products/tib-71
Experimental models: organisms/strains
RIPcre	In house	N/A
LRH-1lox/lox	Procured from Dr. Schoonjans, EPFL, CH, in house	N/A
pdx1PBCreERTM	Procured from Dr. Gannon, Vanderbilt University, USA, in house	N/A
B6.129X1-Gt(ROSA)26Sortm1(EYFP)Cos/J	The Jackson Laboratory	Strain #:006148 RRID:IMSR_JAX:006148
C57BL/6J	Charles Rivers/Janvier Labs	strain code 027/SC-C57J-F
Oligonucleotides
See Table S1 for primer sequences	Metabion International AG, DE	N/A
Software and algorithms
Fiji	ImageJ	https://imagej.net/software/fiji/downloads
Prism	GraphPad	https://www.graphpad.com/
Adobe Photoshop	Adobe	https://www.adobe.com/es/
ImageJ	Imagej	https://imagej.nih.gov/ij/