Table 3.
Univariate Logistic Regression: Associations Between ICUAW at ICU Discharge and Gait Dependence at Hospital Discharge with Baseline and Clinical Variables.
| Dependent variable | Cohort characteristics | Odds ratios [95% CI] | P value |
|---|---|---|---|
| ICUAW | IMV duration (1 day) | 1.201 [1.079−1.337] | <0.001 |
| ICU Length of stay (1 day) | 1.159 [1.059−1.268] | <0.001 | |
| NMBA use (yes/no) | 9.059 [1.708−48.034] | 0.010 | |
| NMBA duration (1 day) | 1.145 [0.999−1.313] | 0.052 | |
| NMBA total cum. dose (mg) | 1 [1−1.001] | 0.446 | |
| Gait dependence | Age (years) | 1.126 [1.053−1.203] | <0.001 |
| CCI (1 point) | 1.606 [1.113−2.317] | 0.011 | |
| MRC-SS at ICU discharge (1 point) | 0.943 [0.9−0.989] | 0.015 | |
| IMV duration (1 day) | 1.128 [1.050−1.212] | <0.001 | |
| ICU Length of stay (1 day) | 1.1 [1.037−1.168] | 0.002 | |
| NMBA duration (1 day) | 1.150 [1.014−1.304] | 0.029 | |
| NMBA total cum. dose (mg) | 1 [1−1.001] | 0.195 |
* Only independent variables with p < 0.05 in the between-group comparison are shown. Variables with not significant between-group differences did not reach statistical significance in the univariate analysis.
Abbreviations: ICUAW = intensive care unit acquired weakness, ICU = Intensive Care Unit, CI -Confidence Interval, PaO2/FiO2 = partial pressure of oxygen to fraction of inspired oxygen (worst values within 24 hours of ICU admission), IMV = invasive mechanical ventilation, NMBA = Neuromuscular Blocking Agents (continuous perfusion only), CCI = Charlson Comorbidity Index, APACHE II = Acute Physiology and Chronic Health Evaluation (range 0-71, higher scores indicate more severe illness), MRC- SS = Medical Research Council Sum Score (range 0-60, higher values indicate more strength).