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. 2022 Apr 27;23(6):414. doi: 10.3892/etm.2022.11341

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Copyright: © Ji et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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RV treatment reduces the PI3K/AKT/mTOR signaling pathway in UVECs. (A and B) Effects of RV treatment on (A) mRNA and (B) protein expression levels of total and phosphorylated PI3K and AKT, and mTOR in UVECs compared with the control. (C and D) Effects of PI3KIR on (C) mRNA and (D) protein expression levels of total and phosphorylated AKT and mTOR in UVECs compared with the control. (E and F) Effects of PI3KOR on the (E) mRNA and (F) protein expression levels of total and phosphorylated AKT and PI3K, and mTOR in UVECs compared with the control. (G and H) Effects of PI3KOR on RV-regulated (G) mRNA and (H) protein expression levels of total and phosphorylated AKT, and mTOR in UVECs compared with the control. ^**P<0.01. UVECs, umbilical vein endothelial cells; PI3KIR, PI3K inhibitor; PI3KOR, PI3K overexpression; RV, resveratrol; p, phosphorylated.