Skip to main content
. 2022 May 18;7(7):715–722. doi: 10.1001/jamacardio.2022.1061

Figure 2. Comparisons of Individual Genetic and Nongenetic Risk Factors for Hypertrophic Cardiomyopathy (HCM).

Figure 2.

A, Hazard ratios for HCM (n = 129 incident cases), calculated using Cox proportional-hazards models adjusting for age, sex, genotyping array, and principal components 1 through 5. B, Proportion of population-wide HCM susceptibility explained by genetic and nongenetic risk factors. High polygenic risk is defined as a score in the top quintile of polygenic risk score (PRS) distribution. Error bars denote 95% CI. Data analysis was conducted in the UK Biobank. ACMG indicates American College of Medical Genetics and Genomics; AF, atrial fibrillation; CAD, coronary artery disease.