Figure 3. Cumulative Performance of Genetic and Nongenetic Risk Factors for Hypertrophic Cardiomyopathy (HCM).

A, Cumulative area under the receiver operator characteristic curve (AUC) for HCM (n = 129 incident cases). The vertical line represents the AUC for the baseline logistic regression model inclusive of age, sex, and principal components (PCs) 1 through 5. Clinical and genetic factors were then added sequentially as predictors on top of the baseline model. B, Cumulative variance in disease susceptibility explained. Plotted values are calculated as improvement in r² on the liability scale on adding risk factors to a logistic regression model consisting of age, sex, and PCs 1-5 in a stepwise fashion. High polygenic risk is defined as an individual with a score in the top quintile of polygenic risk score (PRS) distribution. Data analysis was conducted in the UK Biobank. Error bars denote 95% CI. ACMG indicates American College of Medical Genetics and Genomics; AF, atrial fibrillation; CAD, coronary artery disease; HTN, hypertension.