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Study design
(A) Study workflow.
(B) Four methods of selecting genes included in each PTRS model.
PRS, polygenic risk score; PTRS, polygenic transcriptome risk score; 279 variants are the SNPs used to derive weighted genetic risk score for COPD in Shrine’s work; TWAS, transcriptome-wide association study; S-PrediXcan, Summary-PrediXcan.
