Table 1.
Characteristics of the study-participants included in the analyses
| Stratum | Study | NHW | AA | HIS | Age, years | Female (%) | Smoking pack-years | FEV1%predicted | FEV1/FVC ratio | Moderate-to-severe COPD | Severe COPD |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Population-and family-based | ARIC | 5,717 | 1,458 | – | 62.81 ± 9.69 | 3,998 (56) | 17.28 ± 23.41 | 92 ± 19 | 0.73 ± 0.09 | 1,115 | 199 |
| CARDIA | 1,386 | 1,373 | – | 42.17 ± 6.62 | 1,525 (55) | 0.71 ± 1.58 | 95 ± 14 | 0.79 ± 0.06 | – | – | |
| CFS | 402 | 388 | – | 47.21 ± 16.07 | 432 (55) | 10.29 ± 16.26 | 91 ± 20 | 0.79 ± 0.07 | 64 | 16 | |
| CHS | 2,321 | 312 | – | 78.74 ± 6.09 | 1,574 (60) | 16.08 ± 24.85 | 91 ± 25 | 0.72 ± 0.11 | 500 | 155 | |
| FHS | 3,321 | – | – | 48.86 ± 11.85 | 1,771 (53) | 6.72 ± 15.76 | 96 ± 15 | 0.76 ± 0.07 | 239 | 26 | |
| HCHS/SOL | – | – | 6,750 | 46.65 ± 13.64 | 3,969 (59) | 7.43 ± 15.97 | 92 ± 15 | 0.80 ± 0.07 | 394 | 69 | |
| JHS | – | 2,511 | – | 54.54 ± 12.54 | 1,621 (65) | – | 93 ± 18 | 0.81 ± 0.08 | 123 | 26 | |
| MESA | 1,580 | 983 | 879 | 66.40 ± 9.84 | 2,088 (52) | 10.69 ± 20.90 | 94 ± 18 | 0.75 ± 0.08 | 408 | 52 | |
| Total | 14,727 | 7,025 | 7,629 | – | – | – | – | – | 2,843 | 543 | |
| COPD-enriched | COPDGene | 6,609 | 3,258 | – | 59.55 ± 9.04 | 4,602 (47) | 44.27 ± 24.87 | 73 ± 26 | 0.65 ± 0.16 | 3,981 | 2,022 |
| SPIROMICS | 1,535 | 369 | – | 63.50 ± 9.06 | 886 (47) | 47.60 ± 27.91 | 67 ± 27 | 0.59 ± 0.16 | 1,115 | 547 | |
| Total | 8,144 | 3,627 | – | – | – | – | – | – | 5,096 | 2,569 |
Mean ± standard deviation. ARIC, Atherosclerosis Risk in Communities; CARDIA, Coronary Artery Risk Development in Young Adults; CFS, Cleveland Family Study; CHS, Cardiovascular Health Study; FHS, Framingham Heart Study; HCHS/SOL, Hispanic Community Health Study/Study of Latinos; JSH, Jackson Heart Study; MESA, Multi-Ethnic Study of Atherosclerosis; COPDGene, Genetic Epidemiology of COPD; SPIROMICS, Sub-Populations and Intermediate Outcome Measures in COPD Study; NHW, non-Hispanic White; AA, African American; HIS, Hispanic; FEV1, forced expiratory volume in 1 s; FEV1/FVC ratio, FEV1 ratio to forced vital capacity.