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Histogram of I2 statistics for genes with strong locus-level colocalization but weak TWAS signals
The figure indicates that genes with strong locus-level colocalization but weak TWAS signals are more likely to have high I2 values than those with strong TWAS signals. This phenomenon is similar to findings for genes with strong variant-level colocalization but weak TWAS signals, indicating that both sets of genes are most likely enriched with cases of horizontal pleiotropy.
