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. 2022 May 19;65(8):1339–1352. doi: 10.1007/s00125-022-05713-6

Table 1.

Type 2 diabetes-related mortality and DALYs indicators by country income tiers, 1990–2019

Variable Mortality cases
(×103, 95% CI)
ASDR
(/100,000, 95% CI)
DALYs
(No. ×103, 95% CI)
Age-standardised DALY rate
(/100,000, 95% CI)
1990 2019 Annual growth (%) 1990 2019 Annual growth (%) 1990 2019 Annual growth (%) 1990 2019 Annual growth (%)
Global
 All factors 606 (573, 638) 1473 (1372, 1566) 4.9 (4.6, 5.2) 16.7 (15.7, 17.5) 18.5 (17.2, 19.7) 0.4 (0.1, 0.7) 25,478 (21,701, 29,776) 66,300 (55,477, 79,005) 5.5 (4.7, 6.3) 628.3 (537.2, 730.9) 801.5 (670.6, 954.4) 1.0 (0.2, 1.7)
 Metabolic factors
  High BMI 191 (118, 276) 619 (436, 815) 7.7 (7.1, 8.3) 5.0 (3.0, 7.3) 7.6 (5.3, 10.0) 1.8 (0.4, 3.2) 9391 (5778, 13,913) 34,422 (24,110, 46,308) 9.2 (8.7, 9.7) 224.8 (137.9, 332.0) 411.1 (287.5, 552.2) 2.9 (1.6, 4.1)
 Environmental factors
  Ambient particulate matter pollution 56 (37, 79) 197 (136, 258) 8.7 (7.8, 9.6) 1.6 (1.0, 2.2) 2.5 (1.7, 3.2) 2.0 (0.6, 3.4) 2330 (1463, 3318) 9034 (6135, 12,213) 9.9 (9.1, 10.7) 58.4 (36.6, 83.1) 109.0 (74.1, 147.2) 3.0 (1.6, 4.4)
  Household air pollution from solid fuels 75 (49, 121) 96 (61, 138) 1.0 (−0.9, 2.9) 2.0 (1.3, 3.2) 1.2 (0.7, 1.7) −1.4 (−3.7, 0.9) 3126 (1984, 5001) 3922 (2432, 5851) 0.9 (−1.1, 2.9) 75.9 (48.1, 120.4) 47.1 (29.2, 70.4) −1.3 (−3.6, 1.0)
 Tobacco
  Smoking 67 (56, 80) 121 (99, 145) 2.7 (1.9, 3.6) 1.8 (1.5, 2.1) 1.5 (1.2, 1.8) −0.5 (−1.5, 0.4) 3278 (2559, 4071) 6541 (4997, 8273) 3.4 (2.3, 4.5) 79.2 (61.9, 97.9) 78.1 (59.6, 98.7) −0.1 (−1.2, 1.1)
  Second-hand smoke 56 (22, 84) 123 (48, 189) 4.2 (1.7, 6.7) 1.5 (0.6, 2.3) 1.5 (0.6, 2.4) 0.1 (−2.8, 3.0) 2462 (925, 3868) 5803 (2138, 9191) 4.7 (2.1, 7.3) 60.0 (22.5, 94.1) 69.7 (25.7, 110.5) 0.6 (−2.4, 3.5)
 Dietary
  Diet low in fruits 41 (26, 57) 88 (56, 126) 4.0 (2.4, 5.7) 1.1 (0.7, 1.5) 1.1 (0.7, 1.6) 0 (−1.9, 1.9) 1784 (1112, 2574) 3946 (2370, 5908) 4.2 (2.3, 6.1) 43.6 (27.0, 62.9) 47.6 (28.6, 71.3) 0.3 (−1.7, 2.3)
  Diet low in whole grains 31 (11, 46) 73 (26, 108) 4.7 (2.1, 7.2) 0.9 (0.3, 1.3) 0.9 (0.3, 1.4) 0.2 (−2.7, 3.2) 1289 (451, 1975) 3300 (1129, 5144) 5.4 (2.7, 8.1) 32.0 (11.2, 49.0) 39.9 (13.7, 62.1) 0.8 (−2.1, 3.8)
  Diet high in red meat 35 (19, 48) 82 (46, 115) 4.7 (3.0, 6.5) 1.0 (0.5, 1.3) 1.0 (0.6, 1.5) 0.2 (−1.8, 2.3) 1524 (873, 2207) 4123 (2434, 5962) 5.9 (4.2, 7.5) 37.9 (21.8, 54.6) 49.8 (29.4, 72.0) 1.1 (−0.9, 3.0)
  Diet high in processed meat 34 (24, 41) 73 (51, 88) 3.9 (2.8, 5.1) 1.0 (0.7, 1.2) 0.9 (0.6, 1.1) −0.2 (−1.5, 1.1) 1447 (996, 1891) 3680 (2431, 4883) 5.3 (3.8, 6.8) 36.5 (25.2, 47.6) 44.6 (29.5, 59.0) 0.8 (−0.8, 2.3)
  Diet high in sugar-sweetened beverages 20 (14, 26) 49 (30, 64) 4.8 (3.1, 6.5) 0.6 (0.4, 0.7) 0.6 (0.4, 0.8) 0.3 (−1.3, 1.9) 864 (578, 1140) 2334 (1385, 3239) 5.9 (3.9, 7.9) 21.4 (14.3, 28.2) 28.2 (16.8, 39.1) 1.1 (−0.7, 2.9)
  Diet low in fibre 20 (10, 31) 41 (17, 65) 3.5 (0.9, 6.0) 0.6 (0.3, 0.9) 0.5 (0.2, 0.8) −0.3 (−3.0, 2.4) 843 (380, 1318) 1779 (727, 2876) 3.8 (1.2, 6.5) 20.9 (9.5, 32.7) 21.6 (8.8, 34.9) 0.1 (−2.7, 2.9)
  Diet low in nuts and seeds 13 (3, 26) 29 (8, 55) 4.2 (1.3, 7.2) 0.4 (0.1, 0.7) 0.4 (0.1, 0.7) 0 (−3.7, 3.7) 551 (129, 1105) 1316 (372, 2568) 4.8 (1.8, 7.7) 13.7 (3.2, 27.4) 15.9 (4.5, 31.1) 0.6 (−3.0, 4.2)
 Physical activity
  Low physical activity 50 (25, 85) 125 (62, 208) 5.2 (3.0, 7.4) 1.5 (0.8, 2.5) 1.6 (0.8, 2.7) 0.3 (−2.2, 2.9) 1720 (782, 3071) 4549 (2189, 7969) 5.7 (3.5, 7.9) 45.0 (21.3, 79.5) 55.9 (27.2, 97.6) 0.8 (−1.8, 3.5)
LICs
 All factors 44 (39, 50) 88 (78, 99) 3.4 (2.9, 3.9) 34.3 (30.5, 38.3) 33.0 (29.6, 36.9) −0.1 (−0.7, 0.4) 1556 (1348, 1797) 3471 (2924, 4100) 4.2 (3.5, 5.0) 999.6 (873.7, 1147.3) 1050.9 (895.7, 1238.9) 0.2 (−0.5, 0.9)
 Metabolic factors
  High BMI 9 (4, 16) 30 (18, 43) 7.5 (6.9, 8.2) 6.2 (2.7, 10.9) 9.6 (5.7, 14.2) 1.9 (−0.1, 3.9) 387 (182, 656) 1438 (903, 2047) 9.4 (9.2, 9.6) 226.0 (105.4, 382.8) 393.7 (245.0, 566.0) 2.6 (0.9, 4.3)
 Environmental factors
  Ambient particulate matter pollution 1 (0, 2) 4 (2, 7) 12.4 (11.9, 12.9) 0.7 (0.2, 1.5) 1.5 (0.7, 2.6) 4.2 (2.1, 6.4) 31 (10, 69) 162 (78, 280) 14.6 (14.6, 14.6) 20.2 (6.3, 45.1) 50.0 (24.0, 85.5) 5.1 (3.1, 7.0)
  Household air pollution from solid fuels 12 (7, 24) 19 (12, 30) 2.0 (−0.1, 4.0) 9.4 (5.7, 18.5) 7.1 (4.7, 11.2) −0.8 (−3.5, 1.9) 415 (248, 842) 722 (466, 1157) 2.6 (0.6, 4.5) 270.0 (161.9, 537.1) 221.8 (144.0, 352.6) −0.6 (−3.3, 2.0)
 Tobacco
  Smoking 3 (2, 3) 5 (3, 6) 2.5 (1.2, 3.7) 1.9 (1.3, 2.4) 1.5 (1.1, 2.0) −0.6 (−2.0, 0.8) 98 (72, 125) 196 (143, 261) 3.5 (2.2, 4.7) 61.1 (44.6, 77.9) 57.6 (42.2, 76.2) −0.2 (−1.6, 1.2)
  Second-hand smoke 3 (1, 4) 5 (2, 8) 3.4 (0.8, 6.0) 2.0 (0.8, 3.2) 1.9 (0.7, 3.0) −0.2 (−3.2, 2.8) 101 (38, 160) 230 (83, 369) 4.4 (1.7, 7.1) 64 (24.1, 101.5) 67.6 (24.6, 108.6) 0.2 (−2.8, 3.2)
 Dietary
  Diet low in fruits 3 (2, 5) 7 (4, 9) 3.4 (1.8, 5.0) 2.6 (1.8, 3.6) 2.6 (1.7, 3.5) −0.1 (−1.8, 1.6) 120 (78, 162) 265 (170, 371) 4.2 (2.6, 5.8) 77.2 (50.8, 104.0) 80.9 (52.6, 112.6) 0.2 (−1.5, 1.9)
  Diet low in whole grains 2 (1, 3) 4 (1, 7) 3.3 (0.5, 6.1) 1.7 (0.6, 2.6) 1.6 (0.5, 2.5) −0.2 (−3.4, 3.0) 77 (26, 119) 170 (55, 263) 4.1 (1.4, 6.9) 50.2 (16.7, 77.5) 51.9 (16.8, 79.9) 0.1 (−3.0, 3.3)
  Diet high in red meat 1 (0, 2) 2 (1, 4) 3.7 (0.5, 6.8) 0.9 (0.2, 1.4) 0.9 (0.2, 1.4) 0 (−3.7, 3.7) 43 (11, 71) 99 (25, 169) 4.6 (1.5, 7.6) 26.8 (6.5, 44.8) 29.4 (7.3, 49.7) 0.3 (−3.2, 3.9)
  Diet high in processed meat 2 (1, 2) 4 (2, 5) 4.0 (2.4, 5.7) 1.3 (0.7, 1.7) 1.4 (0.8, 1.8) 0.2 (−1.8, 2.1) 65 (36, 84) 159 (90, 211) 5.0 (3.4, 6.7) 40.5 (21.9, 52.7) 46.9 (26.5, 61.9) 0.5 (−1.4, 2.4)
  Diet high in sugar-sweetened beverages 1 (1, 2) 2 (2, 3) 2.5 (1.3, 3.7) 1.0 (0.8, 1.2) 0.8 (0.6, 1.1) −0.6 (−1.7, 0.6) 44 (34, 55) 85 (59, 111) 3.2 (1.8, 4.6) 28.9 (22.5, 35.8) 26.3 (19.0, 33.8) −0.3 (−1.6, 0.9)
  Diet low in fibre 1 (0, 1) 2 (1, 3) 3.3 (0.6, 6.0) 0.7 (0.3, 1.2) 0.6 (0.2, 1.1) −0.3 (−3.5, 2.9) 31 (11, 52) 70 (27, 119) 4.4 (1.8, 6.9) 20.4 (7.2, 34.0) 21.2 (8.1, 35.6) 0.1 (−2.9, 3.2)
  Diet low in nuts and seeds 1 (0, 2) 1 (0, 3) 2.4 (−1.2, 6.1) 0.6 (0.1, 1.2) 0.5 (0.1, 1.1) −0.5 (−4.6, 3.5) 27 (7, 54) 53 (10, 111) 3.2 (−0.4, 6.9) 17.8 (4.4, 35.4) 16.3 (3.3, 34.3) −0.3 (−4.2, 3.7)
 Physical activity
  Low physical activity 2 (1, 4) 4 (2, 8) 4.7 (2.3, 7.1) 1.6 (0.7, 3.0) 1.8 (0.8, 3.2) 0.4 (−2.5, 3.3) 57 (24, 113) 147 (61, 289) 5.5 (2.9, 8.2) 40.9 (17.9, 79.8) 49.7 (21.8, 93.3) 0.7 (−2.2, 3.7)
LMICs
 All factors 201 (182, 224) 649 (596, 704) 7.7 (7.5, 7.9) 22.8 (20.6, 25.5) 31.2 (28.5, 33.9) 1.3 (0.9, 1.7) 8246 (7050, 9516) 27,137 (23,209, 31,659) 7.9 (7.3, 8.5) 760.0 (656.1, 873.0) 1108.3 (951.6, 1285.5) 1.6 (0.9, 2.3)
 Metabolic factors
  High BMI 41 (20, 68) 253 (175, 337) 18.0 (20.4, 15.7) 3.9 (1.9, 6.6) 10.7 (7.2, 14.5) 6.0 (5.4, 6.6) 2045 (1055, 3369) 13,035 (9058, 17,287) 18.5 (20.8, 16.3) 171.2 (87.5, 284.8) 495.1 (340.2, 660.3) 6.5 (6.1, 6.9)
 Environmental factors
  Ambient particulate matter pollution 12 (7, 20) 88 (60, 119) 21.7 (23.8, 19.6) 1.4 (0.7, 2.3) 4.3 (2.9, 5.7) 7.3 (6.9, 7.6) 514 (282, 844) 3761 (2547, 5174) 21.8 (23.6, 19.9) 47.6 (26.4, 78.4) 154.0 (104.5, 210.8) 7.7 (7.3, 8.2)
  Household air pollution from solid fuels 39 (25, 64) 60 (37, 87) 1.8 (0, 3.7) 4.5 (2.9, 7.4) 2.9 (1.8, 4.3) −1.2 (−3.5, 1.1) 1565 (983, 2620) 2436 (1507, 3599) 1.9 (0, 3.8) 146.1 (92.1, 242.2) 100.3 (62.5, 148.0) −1.1 (−3.4, 1.3)
 Tobacco
  Smoking 19 (15, 24) 50 (39, 60) 5.4 (4.5, 6.3) 2.0 (1.6, 2.5) 2.2 (1.7, 2.7) 0.3 (−0.7, 1.4) 836 (649, 1038) 2230 (1720, 2772) 5.8 (4.8, 6.7) 75.1 (58.4, 93.3) 88.5 (68.5, 109.7) 0.6 (−0.5, 1.7)
  Second-hand smoke 21 (8, 32) 62 (24, 94) 6.9 (4.5, 9.2) 2.3 (0.9, 3.6) 3.0 (1.1, 4.5) 0.9 (−1.9, 3.7) 843 (317, 1318) 2604 (962, 4048) 7.2 (4.7, 9.7) 77.9 (29.4, 121.2) 106.0 (39.5, 164.3) 1.2 (−1.6, 4.0)
 Dietary
  Diet low in fruits 19 (13, 25) 54 (37, 74) 6.3 (4.8, 7.8) 2.2 (1.5, 2.8) 2.6 (1.8, 3.6) 0.8 (−0.7, 2.3) 800 (550, 1072) 2317 (1552, 3207) 6.5 (5.0, 8.1) 73.6 (50.9, 98.7) 95.0 (63.9, 131.2) 1.0 (−0.6, 2.6)
  Diet low in whole grains 10 (3, 14) 30 (10, 46) 7.6 (5.1, 10.0) 1.1 (0.4, 1.6) 1.5 (0.5, 2.2) 1.2 (−1.7, 4.0) 394 (137, 602) 1286 (450, 1992) 7.8 (5.3, 10.3) 36.9 (13.1, 56.2) 52.6 (18.2, 81.0) 1.5 (−1.4, 4.3)
  Diet high in red meat 4 (1, 7) 15 (5, 24) 9.5 (7.3, 11.8) 0.5 (0.1, 0.7) 0.7 (0.2, 1.1) 1.9 (−1.1, 4.9) 171 (54, 282) 648 (215, 1050) 9.6 (7.1, 12.0) 15.8 (4.9, 26.0) 26.0 (8.6, 42.1) 2.2 (−0.7, 5.1)
  Diet high in processed meat 5 (3, 6) 19 (13, 24) 9.7 (8.6, 10.8) 0.6 (0.4, 0.7) 0.9 (0.6, 1.1) 2.0 (0.7, 3.3) 214 (141, 273) 827 (551, 1068) 9.9 (8.6, 11.1) 19.7 (12.9, 25.3) 33.2 (22.1, 42.9) 2.4 (1.0, 3.8)
  Diet high in sugar-sweetened beverages 5 (4, 7) 17 (11, 22) 7.0 (5.1, 9.0) 0.6 (0.5, 0.8) 0.8 (0.5, 1.0) 0.8 (−0.6, 2.2) 210 (153, 267) 694 (424, 957) 8.0 (5.6, 10.3) 19.8 (14.8, 25.0) 28.2 (17.5, 38.5) 1.5 (−0.2, 3.1)
  Diet low in fibre 8 (5, 12) 21 (10, 33) 5.2 (2.7, 7.7) 1.0 (0.5, 1.4) 1.0 (0.5, 1.6) 0.2 (−2.2, 2.6) 331 (168, 492) 846 (384, 1323) 5.4 (2.9, 7.9) 30.9 (15.9, 45.7) 35.0 (16.0, 54.6) 0.4 (−2.0, 2.9)
  Diet low in nuts and seeds 5 (1, 9) 15 (6, 26) 7.2 (5.2, 9.3) 0.5 (0.2, 1.1) 0.7 (0.3, 1.3) 1.1 (−2.0, 4.3) 207 (63, 394) 678 (256, 1208) 7.8 (5.7, 9.9) 19.1 (5.6, 36.7) 27.6 (10.5, 49.2) 1.5 (−1.5, 4.5)
 Physical activity
  Low physical activity 14 (6, 24) 47 (23, 80) 8.5 (6.5, 0.5) 1.8 (0.9, 3.1) 2.5 (1.3, 4.2) 1.5 (−1.0, 4.0) 452 (201, 845) 1501 (694, 2690) 8.0 (5.8, 10.2) 47.4 (22.1, 86.6) 68.1 (32.7, 119.9) 1.5 (−1.1, 4.1)
UMICs
 All factors 195 (185, 207) 492 (452, 529) 5.3 (4.9, 5.7) 14.5 (13.6, 15.4) 15.5 (14.2, 16.7) 0.2 (−0.1, 0.6) 9244 (7760, 10,940) 23,228 (19,229, 28,120) 5.2 (4.4, 6.1) 589.0 (496.8, 696.7) 684.4 (566.8, 825.6) 0.6 (−0.3, 1.4)
 Metabolic factors
  High BMI 73 (47, 102) 227 (159, 300) 7.3 (6.4, 8.1) 4.9 (3.1, 7.1) 6.8 (4.7, 9.1) 1.3 (−0.2, 2.9) 3712 (2309, 5457) 12,654 (8594, 17,371) 8.3 (7.4, 9.2) 225.3 (138.5, 331.6) 366 (249.6, 502.2) 2.2 (0.7, 3.6)
 Environmental factors
  Ambient particulate matter pollution 20 (13, 29) 79 (56, 102) 10.1 (9.7, 10.5) 1.5 (1.0, 2.1) 2.5 (1.8, 3.2) 2.2 (1.0, 3.5) 915 (560, 1346) 3814 (2623, 5204) 10.9 (10.5, 11.4) 58.9 (36.4, 86.0) 111.9 (77.0, 152.7) 3.1 (1.8, 4.4)
  Household air pollution from solid fuels 22 (14, 32) 16 (8, 27) −0.9 (−3.1, 1.3) 1.6 (1.0, 2.3) 0.5 (0.3, 0.8) −2.4 (−4.7, −0.1) 1081 (678, 1602) 737 (362, 1266) −1.1 (−3.5, 1.3) 68.8 (43.4, 101.6) 21.6 (10.6, 37.0) −2.4 (−4.8, 0.1)
 Tobacco
  Smoking 24 (20, 28) 45 (36, 55) 3.1 (2.2, 4.1) 1.6 (1.4, 1.9) 1.4 (1.1, 1.6) −0.6 (−1.5, 0.3) 1274 (1004, 1587) 2619 (1967, 3304) 3.6 (2.5, 4.8) 78.5 (61.8, 97.4) 75.1 (56.4, 94.6) −0.1 (−1.3, 1.0)
  Second-hand smoke 22 (9, 33) 44 (18, 68) 3.5 (1.0, 6.0) 1.6 (0.6, 2.5) 1.4 (0.5, 2.1) −0.5 (−3.5, 2.5) 1044 (398, 1637) 2222 (826, 3547) 3.9 (1.2, 6.5) 66.5 (25.4, 103.9) 64.8 (24.1, 103.6) −0.1 (−3.1, 2.9)
 Dietary
  Diet low in fruits 11 (6, 16) 18 (8, 31) 2.3 (−0.5, 5.1) 0.8 (0.4, 1.2) 0.6 (0.2, 1.0) −1.0 (−3.5, 1.6) 557 (311, 859) 842 (364, 1523) 1.8 (−1.0, 4.6) 35.2 (19.6, 54.2) 24.9 (10.8, 45.0) −1.0 (−3.7, 1.7)
  Diet low in whole grains 10 (4, 15) 25 (9, 37) 4.9 (2.3, 7.5) 0.8 (0.3, 1.1) 0.8 (0.3, 1.2) 0.1 (−2.9, 3.0) 480 (170, 748) 1190 (412, 1887) 5.1 (2.4, 7.8) 30.8 (11.0, 47.8) 34.9 (12.1, 55.4) 0.5 (−2.5, 3.5)
  Diet high in red meat 13 (6, 18) 40 (24, 56) 7.4 (6.5, 8.4) 0.9 (0.5, 1.3) 1.3 (0.7, 1.8) 1.2 (−0.7, 3.1) 638 (333, 950) 2081 (1276, 2958) 7.8 (6.8, 8.8) 40.2 (20.9, 60.1) 60.7 (37.1, 86.3) 1.8 (−0.1, 3.6)
  Diet high in processed meat 7 (4, 8) 20 (12, 24) 6.5 (5.0, 8.1) 0.5 (0.3, 0.6) 0.6 (0.4, 0.8) 0.8 (−0.8, 2.4) 347 (215, 461) 1033 (597, 1389) 6.8 (5.0, 8.6) 22.0 (13.7, 29.2) 30.1 (17.4, 40.6) 1.3 (−0.5, 3.1)
  Diet high in sugar-sweetened beverages 7 (5, 9) 18 (11, 24) 5.4 (3.5, 7.4) 0.5 (0.4, 0.7) 0.6 (0.3, 0.8) 0.3 (−1.3, 2.0) 340 (235, 449) 872 (512, 1221) 5.4 (3.3, 7.5) 21.6 (14.9, 28.5) 25.7 (15.1, 35.9) 0.6 (−1.1, 2.4)
  Diet low in fibre 5 (2, 9) 10 (4, 17) 3.1 (0.4, 5.8) 0.4 (0.2, 0.7) 0.3 (0.1, 0.5) −0.7 (−3.7, 2.3) 274 (115, 442) 497 (190, 833) 2.8 (0, 5.6) 17.5 (7.3, 28.1) 14.7 (5.6, 24.7) −0.5 (−3.6, 2.5)
  Diet low in nuts and seeds 4 (1, 8) 9 (2, 18) 3.7 (0.2, 7.3) 0.3 (0.1, 0.6) 0.3 (0.1, 0.6) −0.4 (−4.6, 3.7) 200 (34, 423) 397 (66, 844) 3.4 (−0.3, 7.0) 12.9 (2.2, 27.2) 11.7 (2.0, 24.9) −0.3 (−4.5, 3.9)
 Physical activity
  Low physical activity 17 (9, 28) 47 (24, 75) 6.2 (4.2, 8.2) 1.4 (0.7, 2.2) 1.5 (0.8, 2.5) 0.4 (−2.0, 2.9) 638 (303, 1102) 1749 (870, 3010) 6.0 (3.9, 8.2) 43.7 (21.4, 75.0) 52.7 (26.3, 89.9) 0.7 (−1.9, 3.3)
HICs
 All factors 165 (155, 171) 242 (217, 256) 1.6 (1.2, 2.0) 12.7 (11.9, 13.2) 9.7 (8.8, 10.2) −0.8 (−1.1, −0.5) 6407 (5343, 7626) 12,403 (9723, 15,525) 3.2 (2.1, 4.3) 508.3 (422.6, 607.0) 601.7 (467.5, 753.6) 0.6 (−0.4, 1.7)
 Metabolic factors
  High BMI 68 (44, 93) 109 (75, 147) 2.1 (0.6, 3.5) 5.3 (3.4, 7.2) 4.7 (3.4, 6.2) −0.4 (−2.0, 1.3) 3237 (2146, 4489) 7260 (5018, 10,010) 4.3 (3.0, 5.6) 262.2 (174.3, 361.8) 375.3 (258.2, 516.2) 1.5 (0, 3.0)
 Environmental factors
  Ambient particulate matter pollution 23 (13, 33) 26 (16, 37) 0.4 (−1.5, 2.3) 1.7 (1.0, 2.5) 1.0 (0.7, 1.5) −1.4 (−3.7, 0.8) 868 (504, 1290) 1291 (762, 1996) 1.7 (−0.3, 3.7) 68.8 (39.9, 102.5) 63.0 (36.8, 97.5) −0.3 (−2.5, 1.9)
  Household air pollution from solid fuels 2 (1, 3) 0 (0, 1) −2.5 (−5.7, 0.7) 0.1 (0.1, 0.2) 0 (0, 0) −2.9 (−6.3, 0.4) 62 (32, 107) 21 (6, 50) −2.3 (−5.5, 1.0) 5.0 (2.5, 8.6) 1.0 (0.3, 2.4) −2.7 (−6.1, 0.6)
 Tobacco
  Smoking 22 (18, 26) 21 (17, 27) −0.1 (−1.1, 1.0) 1.7 (1.4, 2.0) 0.9 (0.8, 1.2) −1.5 (−2.6, −0.4) 1067 (809, 1377) 1489 (1068, 1974) 1.4 (0, 2.7) 86.4 (65.4, 111.7) 76.2 (54.5, 101.1) 0 (−3.1, 3.1)
  Second-hand smoke 10 (4, 16) 12 (4, 18) 0.6 (−2.3, 3.5) 0.8 (0.3, 1.2) 0.5 (0.2, 0.8) −1.3 (−4.5, 2.0) 471 (172, 759) 741 (261, 1239) 2.0 (−0.9, 4.9) 38.3 (14.1, 61.9) 38.1 (13.5, 63.8) −0.4 (−1.8, 1.0)
 Dietary
  Diet low in fruits 8 (3, 12) 10 (4, 16) 0.9 (−1.9, 3.7) 0.6 (0.3, 0.9) 0.4 (0.2, 0.7) −1.2 (−4.2, 1.9) 306 (143, 515) 519 (226, 940) 2.4 (−0.3, 5.1) 24.5 (11.5, 41.3) 25.7 (11.2, 46.4) 0.2 (−2.7, 3.0)
  Diet low in whole grains 9 (3, 13) 13 (5, 19) 1.6 (−1.2, 4.4) 0.7 (0.2, 1.0) 0.5 (0.2, 0.8) −0.8 (−4.0, 2.3) 336 (117, 524) 651 (209, 1056) 3.2 (0.3, 6.2) 26.6 (9.2, 41.6) 31.4 (10.1, 51.2) 0.6 (−2.5, 3.7)
  Diet high in red meat 16 (11, 22) 24 (16, 32) 1.6 (0, 3.1) 1.3 (0.9, 1.7) 1.0 (0.6, 1.3) −0.8 (−2.5, 0.9) 670 (446, 931) 1292 (825, 1864) 3.2 (1.5, 4.9) 53.4 (35.4, 74.1) 63.6 (40.5, 91.7) 0.7 (−1.1, 2.4)
  Diet high in processed meat 20 (15, 25) 30 (21, 38) 1.6 (0.4, 2.9) 1.6 (1.1, 1.9) 1.2 (0.9, 1.5) −0.8 (−2.2, 0.6) 822 (557, 1099) 1660 (1090, 2302) 3.5 (1.9, 5.1) 65.3 (44.2, 87.4) 80.8 (52.6, 112.9) 0.8 (−0.8, 2.5)
  Diet high in sugar-sweetened beverages 6 (3, 9) 12 (6, 16) 2.8 (0.9, 4.6) 0.5 (0.3, 0.7) 0.5 (0.3, 0.7) −0.1 (−2.3, 2.0) 270 (140, 386) 681 (358, 1002) 5.3 (3.3, 7.2) 21.7 (11.3, 30.9) 34.6 (18.5, 51.3) 2.1 (0, 4.1)
  Diet low in fibre 6 (2, 9) 8 (3, 12) 1.2 (−1.6, 4.0) 0.4 (0.2, 0.7) 0.3 (0.1, 0.5) −1.1 (−4.2, 2.1) 207 (79, 343) 364 (133, 620) 2.6 (−0.2, 5.4) 16.4 (6.3, 27.3) 17.5 (6.3, 29.9) 0.2 (−2.9, 3.3)
  Diet low in nuts and seeds 3 (1, 7) 4 (1, 8) 0.7 (−3.1, 4.6) 0.2 (0.1, 0.5) 0.1 (0, 0.3) −1.4 (−5.8, 3.0) 116 (24, 242) 189 (37, 396) 2.1 (−1.5, 5.8) 9.2 (1.9, 19.1) 9.0 (1.7, 18.9) −0.1 (−4.1, 4.0)
 Physical activity
  Low physical activity 18 (9, 29) 27 (14, 44) 1.9 (−0.5, 4.2) 1.4 (0.7, 2.3) 1.0 (0.5, 1.7) −0.8 (−3.6, 1.9) 571 (258, 1025) 1146 (539, 2037) 3.5 (1.0, 5.9) 44.7 (20.1, 81.4) 53.6 (24.8, 98.2) 0.7 (−2.1, 3.5)