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. 2022 May 5;13:867022. doi: 10.3389/fimmu.2022.867022

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Copyright © 2022 Antunes, Cassão, Santos, Borges, Poppe, Gonçalves, Nunes, Recacho, Sousa, Da Silva, Mansur, Stein, Pasquali and De Souza

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Preventive effects of airway–delivered OM–85 during RSV infection. Preventive treatment with OM–85 directly delivered into the airways promote a pro–resolutive homeostatic environment in the lung mucosa, increasing alveolar macrophages, tolerogenic DCs, Treg, and Th1 cell population in locus. This profile enhances viral clearance, increasing IFNβ production, preventing Th2–biased response and ILC2–caused hyperresponsiveness in the lung, ameliorating RSV–induced disease. Image created with https://biorender.com/.