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Baicalin and baicalein triggered programmed cell death in cancer cells via releasing cytochrome-C from mitochondria in the intrinsic pathway. Baicalein activated the TNFR-associated death domain (TRADD) through the extrinsic pathway. In addition, baicalin or baicalein activated autophagy in cancer cells and intervened in the formation of autophagosomes in various steps. The pathways involved the inhibition of AKT/mTOR and activation of AMPK/ULK1
