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Plot of histologic versus symptomatic responses, among studies where dilation is permitted. Symptoms have a high ‘floor effect’ of response with the intercept at 0% histologic response having 73% symptomatic response (β0 = 0.73, P < 0.01). Histology correlates only weakly with symptomatic response (β1 = 0.21, P = 0.35), still with significant heterogeneity (I2 = 77%).
