TABLE 5.

Pain scores on Numerical Pain Rating Scale (NPRS) at each timepoint (n = 10)

Baseline	5 min	10 min	15 min	30 min	45 min	60 min	120 min	180 min	240 min
Visit one (10-mg intranasal ketamine)
7.5 (6–8)	6 (5–8)	6 (5–8)	5 (4–7)	4.5 (2–7)	5 (3–7)	4.5 (3–6)	4.5 (3–7)	5 (3–6)	5 (3–7)
Change from baseline	0.5 (0–2) p = 0.063	0.5 (0–3) p = 0.062	1 (1–2) p = 0.004	1 (1–5) p = 0.004	1 (1–4) p = 0.008	1.5 (1–4) p = 0.002	1.5 (0–3) p = 0.016	2 (0–3) p = 0.016	1.5 (1–2) p = 0.008
Visit two (10-mg intravenous ketamine)
6 (5–8)	1 (0–3)	0 (0–3)	1.5 (0–3)	2.5 (0–5)	3 (0–5)	3.5 (1–5)	3.5 (1–4)	4 (1–5)	3 (1–4)
Change from baseline	4 (3–7) p = 0.002	5.5 (3–7) p = 0.002	4.5 (3–6) p = 0.002	2.5 (1–6) p = 0.004	2.5 (1–5) p = 0.004	2 (1–4) p = 0.004	2 (2–4) p = 0.008	1.5 (1–3) p = 0.008	2 (2–3) p = 0.008
Visit three (30-mg intranasal ketamine)
5.5 (5–7)	5 (4–6)	3 (3–6)	3.5 (3–6)	3.5 (2–6)	3 (2–4)	2.5 (2–3)	3 (2–3)	3 (2–3)	3 (3–4)
Change from baseline	0.5 (0–1) p = 0.06	2 (2–3) p = 0.04	2 (1–3) p = 0.004	2 (1–3) p = 0.004	2 (2–3) p = 0.004	3 (2–3) p = 0.002	2 (2–4) p = 0.002	2 (1–5) p = 0.004	2 (1–2) p = 0.008
Visit four (50-mg intranasal ketamine)
6 (6–8)	5 (3–5)	4 (2–5)	3 (2–5)	2 (2–5)	2 (2–4)	2 (1–5)	2 (1–5)	2.5 (1–6)	5 (2–6)
Change from baseline	1 (0–2) p = 0.047	2 (1–3) p = 0.008	4 (3–4) p = 0.004	4 (2–4) p = 0.004	4 (4–4) p = 0.008	4 (3–5) p = 0.008	4 (2–5) p = 0.008	3 (1–5) p = 0.008	1 (1–4) p = 0.008

Notes: Data presented as median (interquartile range). Shapiro-Wilk test used to test for normality, and more than 80 percent of the time point values were found not to have normal distribution. Therefore, all p-values presented here are for the Wilcoxon signed-rank test for not normally distributed data. Data points with p-values <0.05 are bolded.