Skip to main content
. 2022 May 4;7(19):16584–16592. doi: 10.1021/acsomega.2c00820

Figure 2.

Figure 2

Vaccination with conjugates containing F8–10 haptens elicits hapten-specific IgG titers. Sprague–Dawley rats (n = 6 per group) were given an intramuscular (i.m.) immunization on days 0, 21, 42, and 63 with conjugate vaccines containing the F1 or F8–10 haptens conjugated to CRM. Hapten-specific serum IgG antibody titers were evaluated by ELISA (A) 1 week after the third immunization (day 49), and (B) after completion of drug challenges (day 105). Data are expressed as mean ± SEM. Symbols: *p ≤ 0.05, **p ≤ 0.01, ***p ≤ 0.001, ****p ≤ 0.0001 vs CRM control. Brackets indicate pairwise group comparisons.