Table 2.
Categorized Differentially Regulated Genes.
| sequence | gene name | human homolog(s) | NaAsO2 | DMA | HgCl2 | meHgCl | category | references |
|---|---|---|---|---|---|---|---|---|
| PAR2.3 | aak-1 | PRKAA1, PRKAA2 | – | – | – | 1.5 | AMPK, hhDG | (Kuo et al., 2020, Narbonne and Roy, 2009, WormBase., 2021) |
| ZK909.2 | kin-1 | PRKACA | −1.8 | −1.8 | −1.7 | – | AMPK | (WormBase, 2021) |
| K09E9.4 | – | PKIA, PKIB, PKIG | – | – | −1.7 | −2.0 | AMPK | (WormBase, 2021) |
| ZK1320.4 | cyp-13A10 | CYP3A4, CYP3A43 | – | −2.1 | −1.8 | −2.0 | CYP, hhDG, mib | (WormBase, 2021) |
| T10B9.5 | cyp-13A3 | CYP3A4, CYP3A43 | −1.8 | – | – | – | CYP, hhDG, mib | (WormBase, 2021) |
| K09A11.3 | cyp-14A2 | CYP2U1 | – | −2.1 | – | – | CYP, hhDG, mib | (WormBase, 2021) |
| K09A11.4 | cyp-14A3 | CYP2U1 | – | −1.8 | – | – | CYP, hhDG, mib | (WormBase, 2021) |
| R04D3.1 | cyp-14A4 | CYP2U1 | – | 4.6 | – | – | CYP, iIR, hhDG, mib | (Engelmann et al., 2011, WormBase., 2021) |
| T10H4.10 | cyp-34A1 | CYP2U1 | – | −2.5 | – | – | CYP, DrugR hhDG, mib | (WormBase, 2021) |
| K09D9.2 | cyp-35A3 | CYP2U1 | – | −2.7 | – | – | CYP, DrugR, hhDG, mib | (WormBase, 2021) |
| C49G7.8 | cyp-35A4 | CYP2U1 | 1.6 | – | – | CYP, DrugR, hhDG, mib | (WormBase, 2021) | |
| K07C6.2 | cyp-35B3 | CYP2U1 | – | 1.9 | – | – | CYP, DrugR, hhDG, mib | (WormBase, 2021) |
| F14H3.10 | cyp-35D1 | CYP2U1 | – | 5.6 | – | – | CYP, iIR, DrugR, hhDG, mib | (Troemel et al., 2006, Wong et al., 2007, WormBase., 2021) |
| F01D5.9 | cyp-37A1 | – | – | – | – | −1.5 | CYP | (WormBase, 2021) |
| F55A8.2d | egl-4 | PRKG1 | – | – | −1.8 | – | DAF-2/IIS, Loco, hhDG, mib | (WormBase, 2021) |
| ZK1251.2 | ins-7 | – | −1.9 | −1.9 | – | – | DAF-2/IIS, rSKN-1 | (Murphy et al., 2003, Oliveira et al., 2009) |
| H42K12.1b | pdk-1 | PDPK1 | – | 1.5 | 1.5 | – | DAF-2/IIS, hhDG, OxStrR | (WormBase, 2021) |
| B0454.7 | clec-2 | – | 7.1 | 1.8 | – | – | rDAF-16 | (Nag et al., 2017, WormBase., 2021) |
| F55G11.5 | dod-22 | – | – | −4.2 | – | – | rDAF-16 | (Tepper et al., 2013, Watanabe et al., 2020) |
| F37F2.3 | gst-25 | GSTP1 | 6.9 | 10.4 | – | – | rDAF-16, hhDG | (Minniti et al., 2009) |
| R02D3.6 | grl-19 | – | – | 2.3 | – | 1.6 | rDAF-16, OxStrR | (Kim and Sun, 2007) |
| ZK75.2 | ins-2 | – | −1.6 | −2.2 | −1.8 | – | rDAF-16 | (Murphy et al., 2003) |
| R02D3.1 | aass-1 | AASS | – | – | 1.6 | – | hhDG | (WormBase, 2021) |
| Y74C10AR.3 | abtm-1 | ABCB7 | – | – | 1.6 | – | hhDG, OxStrR | (Gonzalez-Cabo et al., 2011, WormBase., 2021) |
| T11B7.4 | alp-1 | LDB3, PDLIM5 | – | – | – | −2.0 | hhDG | (WormBase, 2021) |
| Y71G12B.1 | chaf-2 | CHAF1B | – | – | – | 1.6 | hhDG | (WormBase, 2021) |
| E04F6.11 | clh-3 | CLCN2 | – | – | 1.7 | – | hhDG | (WormBase, 2021) |
| ZC116.3 | cubn-1 | CUBN | −2.7 | −1.7 | – | −2.5 | hhDG | (WormBase, 2021) |
| F11H8.4 | cyk-1 | DIAPH1, DIAPH2 | – | – | – | −2.3 | hhDG | (WormBase, 2021) |
| ZC477.9 | deb-1 | VCL | – | – | 1.6 | – | hhDG | (WormBase, 2021) |
| T12E12.4 | drp-1 | DNM1L | – | – | 1.6 | – | hhDG | (WormBase, 2021) |
| F43G9.6 | fer-1 | DYSF | 2.5 | −1.5 | – | – | hhDG | (WormBase, 2021) |
| ZK180.1 | gbb-2 | GABBR2 | – | −2.1 | – | – | hhDG, DrugR | (WormBase, 2021) |
| F45H7.2 | gei-1 | DLC1, STARD13 |
– | – | −2.1 | −2.1 | hhDG | (WormBase, 2021) |
| F54D7.3 | gnrr-1 | GNRHR | – | – | 1.8 | – | hhDG | (WormBase, 2021) |
| R03E9.4 | irk-1 | KCNJ14, KCNJ4 | – | 2.1 | – | – | hhDG | (WormBase, 2021) |
| R13A1.2 | kcc-1 | SLC12A4, SLC12A6 | – | – | −2.1 | – | hhDG | (WormBase, 2021) |
| M01B2.1 | kin-30 | KIT, PDGFRA | – | – | – | −3.3 | hhDG | (WormBase, 2021) |
| B0457.1 | lat-1 | ADGRL3 | 1.6 | – | 1.7 | – | hhDG | (WormBase, 2021) |
| R05C11.3 | mca-2 | ATP2B2, ATP2B3 | – | – | 1.5 | – | hhDG | (WormBase, 2021) |
| F32D1.10 | mcm-7 | MCM7 | – | – | – | 1.5 | hhDG, DNArep | (WormBase, 2021) |
| F20B6.3 | mrp-6 | ABCC4 | – | – | – | 2.7 | hhDG | (WormBase, 2021) |
| Y43F8C.12 | mrp-7 | ABCC2 | 1.9 | – | 1.8 | 1.8 | hhDG | (WormBase, 2021) |
| T22E5.5.1 | mup-2 | TNNT1, TNNT3 | – | – | 1.6 | – | hhDG | (WormBase, 2021) |
| Y37A1C.1 | nkcc-1 | SLC12A2 SLC12A3 |
– | – | 1.5 | – | hhDG | (WormBase, 2021) |
| F31B9.1 | npr-33 | AGTR1, GPR15 | – | – | −2.3 | – | hhDG | (WormBase, 2021) |
| C01F6.6 | nrfl-1 | SLC9A3R1 | – | – | 1.6 | – | hhDG | (WormBase, 2021) |
| H12C20.2 | pms-2 | PMS2 | – | – | – | −2.5 | hhDG, DNArep | (WormBase, 2021) |
| K07A3.2 | ptr-12 | PTCHD3 | – | – | – | 2.0 | hhDG | (WormBase, 2021) |
| Y18D10A.7 | ptr-17 | PTCHD3 | – | – | – | 2.1 | hhDG | (WormBase, 2021) |
| F25H5.3 | pyk-1 | PKLR, PKM | – | – | 1.9 | – | hhDG, mib | (WormBase, 2021) |
| T08B2.5 | rbm-5 | RBM10, RBM5 | – | – | 1.7 | – | hhDG, mib | (WormBase, 2021) |
| F25B3.3 | rgef-1 | RASGRP3 | – | – | −2.8 | −3.1 | hhDG | (WormBase, 2021) |
| C06E1.10 | rha-2 | DHX37 | – | – | 1.8 | – | hhDG | (WormBase, 2021) |
| T01H8.1 | rskn-1 | RPS6KA1, RPS6KA2 | – | – | 1.5 | – | hhDG | (WormBase, 2021) |
| C06E7.1 | sams-3 | MAT1A, MAT2A | – | – | 1.7 | – | hhDG, mib | (WormBase, 2021) |
| K11G12.3 | smf-2 | SLC11A1, SLC11A2 |
– | – | – | −2.1 | hhDG | (WormBase, 2021) |
| H21P03.3 | sms-1 | SGMS2 | – | – | 1.5 | – | hhDG | (WormBase, 2021) |
| F55H12.1 | snf-2 | SLC6A11, SLC6A6 | – | – | – | 2.1 | hhDG | (WormBase, 2021) |
| Y46G5A.30 | snf-5 | SLC6A8, SLC6A12 | 2.1 | – | – | – | hhDG, mib | (WormBase, 2021) |
| Y48E1B.14 | snx-14 | SNX14 | – | – | 1.9 | – | hhDG | (WormBase, 2021) |
| T19H12.11 | ugt-10 | UGT1A9, UGT2B28 | 4.5 | – | – | – | hhDG | (WormBase, 2021) |
| F29F11.2 | ugt-34 | UGT1A8, UGT2B15 | 94.5 | – | – | – | hhDG | (WormBase, 2021) |
| ZK1151.1 | vab-10 | DST | 1.7 | 2.0 | – | 2.9 | hhDG | (WormBase, 2021) |
| T08G11.1 | – | VPS13A | – | – | 1.7 | – | hhDG | (WormBase, 2021) |
| Y37A1A.4 | – | RIPOR2, RIPOR3 | −1.5 | – | – | −1.8 | hhDG | (WormBase, 2021) |
| Y48G1C.10 | – | MTMR10, MTMR12 |
– | – | – | 1.6 | hhDG | (WormBase, 2021) |
| Y71H10B.1 | – | NT5C2 | – | – | 1.6 | – | hhDG, OxStrR | (Wang et al., 2010, WormBase., 2021) |
| ZK1073.1 | – | NDRG1, NDRG2 | – | – | 1.5 | – | hhDG | (WormBase, 2021) |
| R05F9.12 | aagr-2 | MGAM | – | – | 1.6 | – | iIR, hhDG | (Engelmann et al., 2011, WormBase., 2021) |
| K02G10.7 | aqp-8 | AQP9 | – | 2.2 | – | – | iIR | (Irazoqui et al., 2010, O'Rourke et al., 2006, WormBase., 2021) |
| ZK896.7 | clec-186 | – | – | – | – | −1.9 | iIR, rMAPK | (Block et al., 2015, WormBase., 2021) |
| C41H7.7 | clec-3 | – | 9.9 | 5.8 | – | – | iIR | (Engelmann et al., 2011, Evans et al., 2008, Muir and Tan, 2008, Troemel et al., 2006) |
| Y46C8AL.3 | clec-70 | – | – | −8.6 | −5.6 | iIR | (WormBase, 2021) | |
| F58E6.7 | hrg-3 | – | −1.9 | −2.3 | −1.9 | −2.0 | iIR | (Engelmann et al., 2011, WormBase., 2021) |
| F26A1.10 | nspd-9 | 1.5 | 2.1 | – | – | iIR | (Engelmann et al., 2011) | |
| C05A9.1 | pgp-5 | ABCB1 | – | −2.3 | – | – | iIR, DrugR | (WormBase, 2021) |
| C05C10.4 | pho-11 | – | 1.6 | 2.2 | – | – | iIR, rDAF-16 | (Bolz et al., 2010, McElwee et al., 2003, Troemel et al., 2006, Wong et al., 2007) |
| C43H6.6 | – | – | – | – | – | 1.7 | iIR | (Engelmann et al., 2011) |
| F01D5.2 | – | – | 4.9 | 3.1 | – | – | iIR | (Engelmann et al., 2011, Ren et al., 2009, Troemel et al., 2006) |
| F26D2.3 | – | GCNT1, GCNT3 | – | – | – | 2.0 | iIR, hhDG | (Engelmann et al., 2011, WormBase., 2021) |
| F47B3.7 | – | – | – | 2.6 | – | – | iIR | (Engelmann et al., 2011, Wong et al., 2007) |
| F48E3.9 | – | – | 2.2 | – | – | – | iIR | (Engelmann et al., 2011) |
| H12I13.5 | – | – | 1.8 | – | – | 1.7 | iIR | (Engelmann et al., 2011) |
| K02D3.1 | – | – | −3.3 | – | – | – | iIR | (Irazoqui et al., 2010, Troemel et al., 2006) |
| R04B5.11 | – | – | – | 2.6 | – | – | iIR | (Engelmann et al., 2011) |
| R09H10.5.2 | – | – | – | – | 2.1 | – | iIR | (Engelmann et al., 2011) |
| T01B6.1 | – | SAPCD2 | 2.1 | – | – | – | iIR | (Engelmann et al., 2011) |
| T28A11.2 | – | – | – | 3.6 | – | – | iIR | (Engelmann et al., 2011) |
| B0207.12 | avr-14 | GLRA3, GLRA4 | 2.0 | 2.6 | 1.6 | – | Loco, DrugR | (WormBase, 2021) |
| K04F10.4 | bli-4 | PCSK5, PCSK6 | −1.5 | – | – | – | Loco, hhDG | (WormBase, 2021) |
| F46C8.5 | ceh-14 | LHX-3, LHX4 | – | – | −1.7 | – | Loco, TxR, hhDG, mib | (WormBase, 2021) |
| C55B7.12 | che-1 | ZNF500 | – | −2.6 | – | – | Loco, TxR, mib | (WormBase, 2021) |
| Y41C4A.4 | crh-1 | ATF1, CREB1, CREM | – | – | −2.5 | – | Loco, TxR, hhDG | (WormBase, 2021) |
| F15A8.5 | dop-1 | DRD1, DRD5 | – | 1.6 | – | – | Loco, hhDG | (WormBase, 2021) |
| C16C2.2 | eat-16 | RGS9, RGS11 | – | – | −1.6 | – | Loco, hhDG | (WormBase, 2021) |
| C06A12.4 | gcy-27 | GUCY2D | – | – | −2.2 | – | Loco, hhDG | (WormBase, 2021) |
| T15H9.3 | hlh-6 | ASCL3 | – | −1.8 | – | – | Loco, TxR | (WormBase, 2021) |
| F58A3.1 | ldb-1 | LDB1, LDB2 | – | – | 1.6 | – | Loco, TxR, rDAF-16 | (Oh et al., 2006, WormBase., 2021) |
| T07H8.4 | mec-1 | – | −1.5 | −1.7 | 1.5 | – | Loco | (WormBase, 2021) |
| E01F3.1 | pde-3 | PDE3A | −1.6 | – | – | – | Loco, TxR, hhDG | (WormBase, 2021) |
| Y11D7A.4 | rab-28 | RAB28 | – | −2.4 | – | – | Loco, hhDG | (WormBase, 2021) |
| M01G5.5 | snf-6 | SLC6A5, SLC6A14 | – | – | 1.6 | – | Loco, hhDG | (WormBase, 2021) |
| C18A3.5 | tiar-1 | TIA1, TIAL1 | – | – | 1.9 | – | Loco, OxStrR | (WormBase, 2021) |
| F56A12.1 | unc-39 | SIX4, SIX6 | – | −1.9 | – | – | Loco, TxR, hhDG | (WormBase, 2021) |
| ZC101.2 | unc-52 | HSPG2 | −1.6 | – | – | – | Loco, hhDG | (WormBase, 2021) |
| C11D2.6 | unc-77 | NALCN | – | – | – | −2.0 | Loco | (WormBase, 2021) |
| C09D1.1 | unc-89 | SPEG | – | – | −1.6 | – | Loco, hhDG | (WormBase, 2021) |
| F35C8.3 | jkk-1 | MAP2K7 | – | – | 1.9 | – | MAPK, Loco, mib | (WormBase, 2021) |
| K02H8.1 | mbl-1 | MBNL1, MBNL2 | −2.0 | 1.9 | – | – | MAPK, TlR, hhDG, mib | (Matilainen et al., 2021, WormBase., 2021) |
| ZC504.4 | mig-15 | MINK1, TNIK | – | – | −1.9 | −2.1 | MAPK, hhDG | (WormBase, 2021) |
| Y95B8A.10 | pde-6 | PDE8A, PDE8B | – | – | – | −2.2 | MAPK, hhDG, mib | (WormBase, 2021) |
| K11E8.1 | unc-43 | CAMK2D | – | – | −2.0 | – | MAPK, TxR, hhDG, mib | (WormBase, 2021) |
| W02G9.2.3 | kel-8 | KLHL8 | – | – | – | 1.6 | rMAPK | (Cui et al., 2007) |
| F21F8.4 | asp-12 | CTSE, PGA4, PGC | – | −1.9 | – | −1.5 | PCD | (WormBase, 2021) |
| Y39B6A.23 | asp-16 | CTSE, PGA4, PGC | – | −2.3 | – | – | PCD | (WormBase, 2021) |
| Y47H9C.4 | ced-1 | MEGF10, MEGF11 | – | – | 1.5 | – | PCD, UPR, iIR, hhDG | (Haskins et al., 2008, WormBase., 2021) |
| F08F1.5 | ced-8 | XKR4, XKR6, XKR7 | – | −1.5 | – | – | PCD | (WormBase, 2021) |
| C09G12.8 | ced-10 | RAC1, RAC2 | – | – | −1.6 | – | PCD, hhDG | (WormBase, 2021) |
| F43G9.11 | ces-1 | SCRT1, SCRT2 | – | −3.4 | – | – | PCD, TxR | (WormBase, 2021) |
| ZK909.4 | ces-2 | DBP,TEF | – | −3.4 | – | – | PCD, TxR, hhDG | (WormBase, 2021) |
| T21H3.3 | cmd-1 | CALM1 | – | – | −1.5 | – | PCD, hhDG, mib | (WormBase, 2021) |
| T12E12.4 | drp-1 | DNM1L | – | – | 1.6 | – | PCD, hhDG | (WormBase, 2021) |
| C02C6.1 | dyn-1 | DNM1, DNM2 | – | – | 1.5 | – | PCD, Loco, hhDG | (WormBase, 2021) |
| C49A1.4 | eya-1 | EYA1, EYA2, EYA4 | – | −1.7 | – | – | PCD, TxR, OxStrR, Loco, UPR, DNArep, hhDG, mib | (WormBase, 2021) |
| M05B5.5 | hlh-2 | TCF3, TCF4, TCF12 | −1.7 | – | – | – | PCD, TxR, hhDG | (WormBase, 2021) |
| Y37A1B.2 | lst-4 | SNX18, SNX33 | – | – | 1.9 | – | PCD | (WormBase, 2021) |
| Y51H1A.6 | mcd-1 | – | – | – | 1.6 | – | PCD, mib | (WormBase, 2021) |
| C33A11.1 | nfki-1 | NFKBIZ | – | – | 1.5 | – | PCD, TxR | (WormBase, 2021) |
| ZK524.1 | spe-4 | – | – | −1.7 | – | – | PCD, Notch | (WormBase, 2021) |
| F11F1.7 | ttr-52 | – | – | −2.4 | −2.0 | −1.8 | PCD | (WormBase, 2021) |
| T19E7.2 | skn-1 | NFE2L1, NFE2L2, NFE2L3 |
– | – | – | 1.5 | SKN-1, TxR, OxStrR, UPR, iIR, rMAPK, hhDG | (WormBase, 2021) |
| K10C2.3 | asp-14 | CTSE, PGA3 | 2.3 | 2.3 | – | – | rSKN-1, iIR, rAMPK, rMAPK | (Bolz et al., 2010, Oliveira et al., 2009, Shin et al., 2011, Troemel et al., 2006, WormBase., 2021) |
| C12C8.2 | cbl-1 | – | 2.1 | – | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009) |
| F35E8.11 | cdr-1 | FAXC | – | 5.0 | – | – | rSKN-1, iIR, rDAF-16, | (Engelmann et al., 2011, Evans et al., 2008, McElwee et al., 2003, Oliveira et al., 2009, Troemel et al., 2006, WormBase., 2021) |
| ZK666.6 | clec-60 | – | −2.2 | −2.2 | – | – | rSKN-1, iIR | (Oliveira et al., 2009, WormBase., 2021) |
| ZK673.9 | clec-143 | – | 2.8 | – | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009, Troemel et al., 2006) |
| K10B2.2 | ctsa-4.1 | CTSA | 1.9 | – | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009, Troemel et al., 2006, Wong et al., 2007) |
| F02C12.5 | cyp-13B1 | CYP3A4, CYP3A5 | – | −3.0 | – | – | rSKN-1, CYP, hhDG, mib | (WormBase, 2021) |
| K10H10.3 | dhs-8 | WWOX | 1.8 | 4.3 | – | – | rSKN-1, hhDG | (Oliveira et al., 2009, WormBase., 2021) |
| K10D11.1 | dod-17 | – | 6.4 | 2.6 | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009, Troemel et al., 2006, WormBase., 2021) |
| C32H11.12 | dod-24 | – | 5.3 | 1.7 | – | – | rSKN-1, iIR | (Block et al., 2015, Bolz et al., 2010, Oliveira et al., 2009, Troemel et al., 2006, WormBase., 2021) |
| Y4C6B.6 | gba-4 | GBA | – | – | – | −4.7 | rSKN-1, iIR, hhDG | (Paek et al., 2012, WormBase., 2021, Zárate-Potes et al., 2020) |
| F37B12.2 | gcs-1 | GCLC | 1.8 | 1.6 | – | – | rSKN-1, OxStrR | (Hasegawa et al., 2008, Oliveira et al., 2009, WormBase., 2021) |
| R107.7 | gst-1 | GSTP1 | 1.6 | 1.7 | – | – | rSKN-1, UPR, hhDG | (Oliveira et al., 2009, Settivari et al., 2013) |
| R03D7.6 | gst-5 | HPGDS | – | 3.0 | – | – | rSKN-1, iIR | (Evans et al., 2008, Oliveira et al., 2009, Troemel et al., 2006, Wong et al., 2007) |
| F11G11.3 | gst-6 | HPGDS | – | 1.8 | – | – | rSKN-1 | (Oliveira et al., 2009, WormBase., 2021) |
| F11G11.2 | gst-7 | HPGDS | – | 1.5 | – | – | rSKN-1 | (Oliveira et al., 2009, WormBase., 2021) |
| F11G11.1 | gst-8 | HPGDS | – | 1.6 | – | – | rSKN-1 | (Oliveira et al., 2009, WormBase., 2021) |
| Y45G12C.2 | gst-10 | GSTP1 | 2.1 | 2.1 | – | – | rSKN-1, OxStrR, hhDG | (Oliveira et al., 2009, Park et al., 2009, Tullet et al., 2008, WormBase., 2021) |
| F37B1.2 | gst-12 | HPGDS | 3.8 | 5.9 | – | – | rSKN-1, OxStrR | (Oliveira et al., 2009, Park et al., 2009, VanDuyn et al., 2010) |
| T26C5.1 | gst-13 | HPGDS | 1.6 | 2.0 | – | – | rSKN-1, iIR | (Oliveira et al., 2009, Park et al., 2009, Troemel et al., 2006, WormBase., 2021) |
| F37B1.3 | gst-14 | HPGDS | 2.8 | 4.0 | – | – | rSKN-1, iIR, OxStrR | (Engelmann et al., 2011, Oliveira et al., 2009, Park et al., 2009) |
| F37B1.5 | gst-16 | HPGDS | 5.8 | 6.8 | – | – | rSKN-1 | (Przybysz et al., 2009) |
| F37B1.8 | gst-19 | HPGDS | −2.2 | −2.2 | – | −3.2 | rSKN-1 | (Oliveira et al., 2009) |
| ZK546.11 | gst-30 | HPGDS | 5.3 | 7.5 | – | – | rSKN-1 | (Przybysz et al., 2009) |
| Y1H11.2 | gst-35 | HPGDS | 2.1 | 6.4 | – | – | rSKN-1 | (Oliveira et al., 2009) |
| C02D5.3 | gsto-2 | GSTO1, GSTO2 | 4.1 | 5.3 | – | – | rSKN-1, OxStrR | (Oliveira et al., 2009, WormBase., 2021) |
| ZK84.3 | ins-5 | – | 1.8 | 2.3 | −1.8 | 2.3 | rSKN-1, rMAPK, rDAF-16 | (Kaplan et al., 2019, Yanase et al., 2020) |
| F35E12.5 | irg-5 | – | 1.9 | 2.7 | – | – | rSKN-1, iIR, rMAPK | (Bolz et al., 2010, Foster et al., 2020, O'Rourke et al., 2006, Oliveira et al., 2009, Pukkila-Worley et al., 2011, Wan et al., 2021) |
| T22G5.6 | lbp-8 | FABP5, PMP2 | – | 7.2 | – | – | rSKN-1, hhDG | (Steinbaugh et al., 2015) |
| K08H10.2 | lea-1 | PLIN4 | – | – | 1.5 | – | rSKN-1, rUPR | (Oliveira et al., 2009, WormBase., 2021) |
| ZK1058.6 | nit-1 | – | 3.6 | 2.2 | – | – | rSKN-1, rMAPK | (Miller et al., 2011, Oliveira et al., 2009) |
| H12D21.1 | nspa-1 | – | 10.7 | 8.7 | – | – | rDAF-16 | (McElwee et al., 2003) |
| ZC412.6 | nspa-5 | – | 9.4 | 7.5 | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009) |
| W06A7.5 | nspa-8 | – | 34.0 | 21.8 | – | – | rSKN-1 | (Oliveira et al., 2009) |
| F57C9.1 | pdxk-1 | PDXK | 2.0 | 2.0 | – | – | rSKN-1, mib | (Oliveira et al., 2009, WormBase., 2021) |
| C55A6.5 | sdz-8 | CBR3 | – | 2.2 | – | – | rSKN-1 | (Oliveira et al., 2009) |
| C15F1.7 | sod-1 | SOD1 | – | 1.7 | – | – | rSKN-1, OxStrR, mib | (Park et al., 2009, WormBase., 2021) |
| H23N18.1 | ugt-13 | UGT1A1, UGT2B28, UGT2B7 | 2.3 | – | – | – | rSKN-1, iIR, hhDG | (Engelmann et al., 2011, Hasegawa et al., 2010, Jones et al., 2013, Troemel et al., 2006) |
| B0348.2 | – | – | −1.5 | −1.9 | – | – | rSKN-1, mib | (Oliveira et al., 2009, WormBase., 2021) |
| C17H12.6 | – | – | 2.2 | – | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009, Troemel et al., 2006) |
| C32H11.3 | – | – | 10.1 | 6.6 | – | – | rSKN-1, iIR | (Engelmann et al., 2011, Oliveira et al., 2009, Troemel et al., 2006) |
| C32H11.4 | – | – | 11.7 | 6.7 | – | – | rSKN-1, iIR | (Muir and Tan, 2008, Oliveira et al., 2009, Yang et al., 2016) |
| F01D5.3 | – | – | 3.4 | 3.3 | – | – | rSKN-1, iIR | (Oliveira et al., 2009, Ren et al., 2009) |
| F01D5.5 | – | – | 2.9 | – | – | – | rSKN-1, iIR | (O'Rourke et al., 2006, Oliveira et al., 2009, Ren et al., 2009, Troemel et al., 2006) |
| F39B2.3 | – | CRYZ | 1.9 | 2.0 | – | – | rSKN-1, TlR | (Oliveira et al., 2009, WormBase., 2021) |
| F55G11.2 | – | – | 10.4 | 2.9 | – | – | rSKN-1, iIR | (Block et al., 2015, Engelmann et al., 2011, Evans et al., 2008, Oliveira et al., 2009, Troemel et al., 2006) |
| F56D5.3 | – | – | 3.1 | 1.8 | – | – | rSKN-1, OxStrR | (Oliveira et al., 2009, Park et al., 2009) |
| H25K10.1 | – | ACP7 | 1.9 | – | – | – | rSKN-1, iIR, mib | (Engelmann et al., 2011, Oliveira et al., 2009, WormBase., 2021) |
| W06H8.2 | – | – | 4.9 | 4.4 | – | – | rSKN-1 | (Przybysz et al., 2009) |
| Y73B6BL.14 | – | – | 2.1 | 2.0 | – | – | rSKN-1, DNArep | (Oliveira et al., 2009, WormBase., 2021) |
| ZK742.4 | – | – | 2.3 | 2.8 | – | – | rSKN-1, rDAF-16 | (McElwee et al., 2003, Oliveira et al., 2009) |
| R186.8 | – | – | −1.8 | – | – | – | TlR | (WormBase, 2021) |
| Y80D3A.2 | emb-4 | AQR | 1.9 | – | – | – | TlR | (WormBase, 2021) |
| Y48G10A.4 | ints-8 | INTS8 | – | – | 1.5 | 1.5 | TlR | (WormBase, 2021) |
| D1007.12 | rpl-24.1 | RPL24 | 1.9 | – | – | – | TlR | (WormBase, 2021) |
| Y92C3B.2 | uaf-1 | U2AF2 | – | – | – | 1.6 | TlR | (WormBase, 2021) |
| Y53C12B.3 | nos-3 | – | – | −2.1 | 2.1 | 2.3 | TlR, iIR | (O'Rourke et al., 2006, Pujol et al., 2008, WormBase., 2021) |
| F29C12.3 | rict-1 | RICTOR | – | – | 1.8 | – | TOR | (Blackwell et al., 2019, WormBase., 2021) |
| F56A3.5 | bro-1 | CBFB | – | −2.0 | – | −2.8 | TxR | (WormBase, 2021) |
| H25P06.2 | cdk-9 | CDK9 | – | – | 1.7 | – | TxR, hhDG | (WormBase, 2021) |
| C16C2.1 | ceh-5 | NOTO, VAX1 | – | −2.8 | – | −1.8 | TxR, hhDG | (WormBase, 2021) |
| ZK265.4 | ceh-8 | RAX | – | −3.1 | – | – | TxR, hhDG | (WormBase, 2021) |
| C13G5.1 | ceh-16 | EN1, EN2 | – | – | −1.8 | – | TxR, hhDG | (WormBase, 2021) |
| C37E2.4 | ceh-36 | OTX1, OTX2 | – | −2.1 | – | – | TxR, hhDG | (WormBase, 2021) |
| ZK993.1 | ceh-45 | GSC | – | – | −2.2 | – | TxR | (WormBase, 2021) |
| F34D6.2 | ceh-87 | ZHX1 | −1.9 | – | – | – | TxR | (WormBase, 2021) |
| T23D8.8 | cfi-1 | ARID3A, ARID3C | 1.7 | 2.1 | – | – | TxR | (WormBase, 2021) |
| F44B9.3 | cit-1.2 | CCNT1 | – | – | 1.8 | – | TxR | (WormBase, 2021) |
| C15C8.2 | cky-1 | NPAS4 | – | −2.1 | – | – | TxR | (WormBase, 2021) |
| C34E10.7 | cnd-1 | NEUROD1 | – | −2.4 | – | – | TxR, hhDG | (WormBase, 2021) |
| F25E2.5 | daf-3 | SMAD4 | – | −1.6 | −2.4 | −2.3 | TxR, TGFβ, hhDG, mib | (WormBase, 2021) |
| C27C12.6 | dmd-4 | DMRT3 | – | −1.8 | – | – | TxR | (WormBase, 2021) |
| F54F7.7 | dot-1.2 | DOT1L | 1.6 | – | – | – | TxR, DNArep | (WormBase, 2021) |
| F49E12.6 | efl-3 | E2F7 | – | −1.9 | – | – | TxR | (WormBase, 2021) |
| C08C3.1 | egl-5 | HOXB8 | – | – | −1.7 | – | TxR | (WormBase, 2021) |
| F40H3.4 | fkh-8 | FOXR1 | – | −2.7 | – | −1.6 | TxR | (WormBase, 2021) |
| C14B9.6 | gei-8 | NCOR1 | 1.7 | – | – | – | TxR | (WormBase, 2021) |
| ZK131.3 | his-9 | – | – | – | – | −1.7 | TxR | (WormBase, 2021) |
| ZK131.5 | his-11 | H2BC1 | – | 1.7 | – | −1.6 | TxR | (WormBase, 2021) |
| F38C2.2 | hlh-17 | BHLHE23 | −1.7 | −1.7 | – | – | TxR | (WormBase, 2021) |
| T01D3.2 | hlh-34 | NPAS1 | – | −3.7 | – | −2.1 | TxR, hhDG | (WormBase, 2021) |
| F43G6.6 | jmjd-1.1 | KDM7A | – | – | −2.1 | – | TxR, hhDG, mib | (WormBase, 2021) |
| F23D12.5 | jmjd-3.2 | KDM6A, UTY | – | −1.7 | – | – | TxR, hhDG | (WormBase, 2021) |
| F20H11.2 | let-765 | SBNO1 | – | – | – | 1.5 | TxR | (WormBase, 2021) |
| T14F9.5 | lin-32 | ATOH1 | – | −1.8 | – | – | TxR, hhDG | (WormBase, 2021) |
| C01H6.5 | nhr-23 | RORC | 1.8 | – | – | – | TxR, hhDG | (WormBase, 2021) |
| C25E10.1 | nhr-30 | – | – | – | −2.5 | – | TxR, mib | (WormBase, 2021) |
| F44C4.2 | nhr-37 | PPARA | – | – | – | −2.2 | TxR, hhDG, mib | (WormBase, 2021) |
| T09A12.4 | nhr-66 | – | – | – | 1.5 | – | TxR, mib | (WormBase, 2021) |
| H12C20.3 | nhr-68 | – | – | – | – | −1.7 | TxR, mib | (WormBase, 2021) |
| C47F8.8 | nhr-81 | – | 1.9 | – | – | – | TxR, mib | (WormBase, 2021) |
| T13F3.3 | nhr-127 | PPARA | – | −4.0 | – | −2.0 | TxR, mib | (WormBase, 2021) |
| C03G6.8 | nhr-147 | HNF4A, HNF4G | – | −3.1 | −2.0 | −2.1 | TxR, hhDG, mib | (WormBase, 2021) |
| C06B8.1 | nhr-150 | PPARA | – | −2.4 | −1.8 | −1.6 | TxR, hhDG, mib | (WormBase, 2021) |
| C54F6.8 | nhr-171 | – | – | −2.4 | −1.9 | −1.8 | TxR, mib | (WormBase, 2021) |
| F47C10.4 | nhr-187 | – | – | −2.3 | −1.7 | – | TxR, mib | (WormBase, 2021) |
| F47C10.7 | nhr-188 | – | – | −1.7 | −1.7 | TxR, mib | (WormBase, 2021) | |
| R07B7.14 | nhr-207 | HNF4A, HNF4G | – | – | – | −1.6 | TxR, hhDG, mib | (WormBase, 2021) |
| T07C5.3 | nhr-214 | – | – | −4.4 | – | – | TxR | (WormBase, 2021) |
| T13F3.2 | nhr-218 | PPARA | – | −3.8 | – | – | TxR, mib | (WormBase, 2021) |
| Y116A8C.18 | nhr-229 | – | – | – | – | −2.6 | TxR, mib | (WormBase, 2021) |
| F21D12.5 | npax-1 | – | – | −1.7 | −1.8 | −1.8 | TxR | (WormBase, 2021) |
| M6.3 | pha-2 | HHEX | −1.6 | −1.9 | – | −1.8 | TxR | (WormBase, 2021) |
| F38A6.1 | pha-4 | FOXA1, FOXA2 | −1.5 | – | – | – | TxR | (WormBase, 2021) |
| C47C12.3 | ref-2 | ZIC1 | – | −2.0 | −1.7 | – | TxR, hhDG | (WormBase, 2021) |
| F26A3.8 | rrf-1 | – | – | – | 1.8 | – | TxR | (WormBase, 2021) |
| T05A10.1 | sma-9 | HIVEP1 | – | – | −1.6 | – | TxR, TGFβ, hhDG | (WormBase, 2021) |
| Y43F4B.3 | set-25 | – | – | – | 1.8 | – | TxR, mib | (Klosin et al., 2017, WormBase., 2021) |
| W02H5.7 | sknr-1 | NFE2L1 | – | – | −1.5 | – | TxR, hhDG | (WormBase, 2021) |
| T08A11.2 | sftb-1 | SF3B1 | – | – | 1.7 | – | TxR, hhDG | (WormBase, 2021) |
| F31E8.3 | tab-1 | BSX | −1.6 | −2.6 | −2.0 | −1.7 | TxR | (WormBase, 2021) |
| T07C4.2 | tbx-8 | EOMES, TBR1 |
– | – | −2.3 | – | TxR, hhDG | (WormBase, 2021) |
| D2030.9 | wdr-23 | DCAF11 | 1.5 | 1.5 | – | – | TxR | (WormBase, 2021) |
| ZC123.3 | zfh-2 | ZFHX3 | – | – | 1.5 | – | Txr, hhDG | (WormBase, 2021) |
| Y48G8AL.10 | znf-236 | ZNF729, ZNF99 | – | – | – | 1.9 | TxR, hhDG | (WormBase, 2021) |
| D1044.6 | – | ZNF318 | 2.1 | – | – | – | TxR | (WormBase, 2021) |
| F26A10.2 | – | ZNF148 | – | – | −2.3 | – | TxR | (WormBase, 2021) |
| M03D4.4 | – | ZNF653 | – | −3.3 | – | – | TxR | (WormBase, 2021) |
| R10E4.11 | – | – | – | – | −1.6 | – | TxR | (WormBase, 2021) |
| Y111B2A.10 | – | ZNF689 | – | −1.7 | −2.4 | −2.6 | TxR | (WormBase, 2021) |
| Y53C10A.15 | – | – | – | – | – | −2.2 | TxR | (WormBase, 2021) |
| Y56A3A.28 | – | – | – | – | −2.4 | – | TxR | (WormBase, 2021) |
| Y57G11C.9 | – | PPHLN1 | – | – | −2.0 | – | TxR | (WormBase, 2021) |
| C03A7.14 | abu-8 | – | – | −2.5 | – | – | UPR | (WormBase, 2021) |
| T10B5.5 | cct-7 | CCT7 | – | – | 1.9 | – | UPR, Loco | (WormBase, 2021) |
| ZK970.2 | clpp-1 | CLPP | −1.8 | – | – | – | UPR, hhDG | (WormBase, 2021) |
| F38A5.13 | dnj-11 | DNAJC2 | – | – | −2.0 | – | UPR | (WormBase, 2021) |
| F39B2.10 | dnj-12 | DNAJA1, DNAJA4 | – | – | 1.6 | – | UPR, mib | (WormBase, 2021) |
| ZK1193.5 | dve-1 | SATB2 | – | – | −1.7 | −1.6 | UPR, TxR, hhdG | (WormBase, 2021) |
| T12D8.8 | hip-1 | ST13 | – | −1.6 | – | – | UPR | (WormBase, 2021) |
| T22A3.2 | hsp-12.1 | HSPB2 | – | −2.0 | – | – | UPR | (WormBase, 2021) |
| Y46H3A.2 | hsp-16.41 | CRYAB, HSPB6 | – | – | −1.6 | – | UPR, iIR, hhDG | (O'Rourke et al., 2006, Wong et al., 2007, WormBase., 2021) |
| T27E4.3 | hsp-16.48 | – | −1.5 | – | – | – | UPR | (WormBase, 2021) |
| C15H9.6.3 | hsp-3 | HSPA5 | – | – | 1.7 | – | UPR | (WormBase, 2021) |
| ZK256.1 | pmr-1 | ATP2C1 | – | – | 1.5 | – | UPR, iIR, OxStrR, hhDG | (Kourtis et al., 2012, Schifano et al., 2019, WormBase., 2021) |
| T02C5.5 | unc-2 | CACNA1A | −1.5 | – | – | – | UPR, TGFβ, hhDG, Loco, mib | (WormBase, 2021) |
| W01B6.1 | cwn-2 | WNT5A | – | −1.7 | −1.6 | – | Wnt, hhDG | (WormBase, 2021) |
| F58G4.4 | sdz-23 | – | −3.4 | −2.6 | −2.3 | −2.7 | rWnt | (Lezzerini and Budovskaya, 2014) |
AMPK, effector of AMP-activated Protein Kinase Signaling; rAMPK, regulated by effectors of AMPK signaling; DAF-2/IIS, effector of the Insulin/Insulin-like Growth Factor Signaling Pathway; rDAF-16, regulated by DAF-16 in the same direction; DNArep, DNA replication/repair; DrugR, response to drug, xenobiotic metabolic process; hhDG, close homology to human disease gene(s); iIR, innate Immune Response (≥1.5x change in the same direction with exposure to ≥ two different pathogens or in ≥ two studies, or role in iIR described); Loco, involved in locomotion or behavior; MAPK, effector of Mitogen-Activated Protein Kinase Signaling (ERK, p38, JUK/SAPK); rMAPK, regulated by effectors of MAPK signaling; mib, metal ion binding; OxStrR, oxidative stress response; PCD, effector of programmed cell death and/or apoptotic process; rSKN-1, regulated by Nrf/SKN-1 in the same direction; TGFβ, effector of transforming growth factor beta receptor signaling pathway; TlR, Translational regulation and machinery; TOR, effector of TOR signaling; TxR, transcriptional regulation and/or histone modification; UPR, effector of unfolded protein/heat shock response; rUPR, regulated by UPR effectors; Wnt, effector of Wnt signaling; rWnt, regulated by Wnt signaling.