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IC50 values for C44-Fc inhibition of ANGPTL3-induced LPL suppression
| Parameter | Protein | |||
|---|---|---|---|---|
| hANGPTL3 (S17-K170) | hANGPTL3 (S17-E460) | mANGPTL3 (S17-T206) | mANGPTL3 (S17-T455) | |
| C44-Fc, IC50 (nM) | 1.6 | 4.6 | 3.6 | 5.4 |
| Evinacumab, IC50 (nM) | 1.7 | 5.4 | 1.8 | 3.7 |
| Control Ab, IC50 (nM) | NB | NB | NB | NB |
The IC50 values were measured using constant concentrations of ANGPTL3 proteins that were less than 2.5-fold of the EC50 values for ANGPTL3-induced suppression of LPL
