Figure 6.

Transcription factors associated with the response to TNFi in monocytes. Using motif-enrichment analysis on the CpG sites associated with TNFi response in monocytes, we identified multiple transcription factors significantly associated with the regulatory changes. A 500 bp region centered around the associated CpG sites in monocytes was used in the analysis. Analysis of differentially methylated positions (DMPs) was performed separately for hypermethylated and hypomethylated CpGs in responders. The motif enrichment score for each transcription factor family (TF) is depicted as a horizontal line; at the end of each line, the significance of the TF association is represented as the diameter of the circle.