Table 5.
Pathways modified in TNFi non-responders at the epigenetic and transcriptomic levels.
| ID | Description | P.adj |
|---|---|---|
| GO:0031098 | stress-activated protein kinase signaling cascade | 2.92E-04 |
| GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling | 3.14E-04 |
| GO:0051403 | stress-activated MAPK cascade | 3.14E-04 |
| GO:0007254 | JNK cascade | 8.28E-03 |
| GO:0002718 | regulation of cytokine production involved in immune response | 1.20E-02 |
| GO:0051092 | positive regulation of NF-kappaB transcription factor activity | 1.20E-02 |
| GO:0046328 | regulation of JNK cascade | 1.62E-02 |
| GO:0002699 | positive regulation of immune effector process | 1.76E-02 |
| GO:0002285 | lymphocyte activation involved in immune response | 3.65E-02 |
| GO:0002456 | T cell mediated immunity | 3.78E-02 |
| GO:0030217 | T cell differentiation | 4.69E-02 |